Human signal transducer and binding assays

Details Human signal transducer and binding assays Human signal transducer and binding assays

1995-03-22

1997-06-17

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530351, 530331, 530330, 530329, 530328, 530327, 530326, 530325, 530324, A61K 3816, C07K 1400

Patent

active

056398581

ABSTRACT:
The invention provides methods and compositions relating to interleukin 12 signal transducers, particularly an isolated human signal transducer and activator of transcription 4 (hStat 4), or a fragment thereof having an hStat 4-specific binding affinity, nucleic acids encoding hStat 4, which nucleic acids may be part of hStat 4-expression vectors and may be incorporated into a recombinant cell, agents which selectively bind hStat 4 or hStat 4 intracellular binding targets, or disrupt the binding of hStat 4 to such intracellular targets, methods of making such agents and hStat 4-specific binding targets in the form of cell surface proteins and nucleic acids. An hStat 4 drug screening assay involves forming mixtures of an hStat 4, an intracellular hStat 4 binding target, and a prospective agent at different concentrations. The mixtures are incubated to permit the binding of the intracellular hStat 4 binding target to the hStat 4 and the mixtures are then analyzed for the presence of such binding. A difference in such binding between the first and second mixtures indicates that the agent is capable of modulating the binding of hStat 4 to an intracellular hStat 4 binding target.

REFERENCES:
Chua et al. (1994) J. Immunol. 153, 128-136.
Yamamoto et al. (1994) Mol and Cell Biol. 14:4342-4349.
Zhong et al. (1994) 91:4806-4810.
Yamamoto et al., "Stat4, a Novel Gamma Interferon Activation Site-Binding Protein Expressed in Early Myeloid Differention", Mol. and Cell Biol., vol. 14, pp. 4342-4349. 1994.

Affiliated with

Also associated with

Rating

Human signal transducer and binding assays does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human signal transducer and binding assays, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human signal transducer and binding assays will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2158742