Human serum albumin-porphyrin complexes with the ability to bind

Details Human serum albumin-porphyrin complexes with the ability to bind Human serum albumin-porphyrin complexes with the ability to bind

1997-08-06

1998-06-30

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 6, 514185, 514322, 530302, 530363, 530385, 530830, 424529, 424530, 424531, A61K 3800, A61K 3516, C07K 100

Patent

active

057734178

ABSTRACT:
The invention is directed to human serum albumin-porphyrin (HSA-P) complexes which are capable of reversible oxygen binding and their uses. These complexes may be used in applications requiring physiological oxygen carriers such as in blood substitute solutions, or in applications requiring plasma expanders. Methods for the production of these complexes are provided. In a specific example, HSA-P complexes are shown to exhibit reversible oxygen binding. In another example, the HSA-P complex does not exhibit appreciable vasoactivity.

REFERENCES:
patent: 5296466 (1994-03-01), Kilbourn et al.
patent: 5334705 (1994-08-01), Bonaventura et al.
patent: 5349054 (1994-09-01), Bonaventura et al.
patent: 5480866 (1996-01-01), Bonaventura et al.
patent: 5629198 (1997-05-01), Mizumoto et al.
Bonaventura et al., 1994, "Oxygen-binding albumins: A novel approach to blood substitutes,", Artif. Cells Blood Substitutes Immobilization Biotechnol. 22(5):Abstract A83.
Komatsu et al., 1995, "O.sub.2 -Transport Albumin: A New Hybrid-Haemoprotein Incorporating Tetraphenylporphyrinatoiron(II) Derivative," Chem. Lett. 9:813-814.
Collman et al., 1994, "Congruent Multiple Michael Addition for the Synthesis of Biomimetic Heme Analogues," J. Am. Chem. Soc. 116: 2681-2682.
Lee and Hirose, 1992, "Partially Folded State of the Disulfide-reduced Form of Human Serum Albumin as an Intermediate for Reversible Denaturation," J. Biol. Chem. 267: 14753-14758.
Bonkovsky et al., 1991, "Intravenous Heme-Albumin in Acute Intermittent Porphyrin: Evidence for Repletion of Hepatic Hemoproteins and Regulatory Heme Pools," Am. J. Gastroenterol. 86: 1050-1056.
Carter and He, 1990, "Structure of Human Serum Albumin," Science 249: 302-303.
Davilla and Harriman, 1990, "Photochemical and Radiolytic Oxidation of a Zinc Porphyrin Bound to Human Serum Albumin," J. Am. Chem. Soc. 112: 2686-2690.
Carter et al., 1989, "Three-Dimensional Structure of Human Serum Albumin," Science 244: 1195-1198.
Datta-Gupta et al., 1989, "Binding Studies of Four Free Base Porphyrins and Six Iron (+3) Porphyrins with Human Serum Albumin," Res. Comm. Chem. Pathol Pharmacol. 63: 289-292.
Datta-Gupta et al., 1988, "Binding Studies of Three Water-Soluble Polycationic Porphyrins with Human Serum Albumin," Res. Comm. Chem. Pathol. Pharmacol. 60: 347-360.
Imai and Kyuno, 1988, "Thermodynamics for Base Binding to Four Atropisomers of Cobalt(II) Picket Fence Porphyrin. Intramolecular Ligand-Ligand Interactions," Inorgan. Chim. Acta 153: 175-182.
Styer, 1988, "Oxygen-transporting Proteins: Myoglobin and Hemoglobin," Chapter 7 Biochemistry (W.H. Freeman and Co., New York), pp. 143-173.
Sharma et al., 1987, "Reaction in Nitric Oxide with Heme Proteins and Model Compounds of Hemoglobin," Biochem. 26: 3837-3843.
Tsuchida, 1987, "Macromolecule-Metal Complexes--Dynamic Separation of Molecular Oxygen through Macromolecule-Metal Complex Membranes," UDC 51: 13-26. (English Abstract).
Imai et al., 1986, "Effects of Polarity on Dioxygen Binding to Cobalt(II) Porphyrins," Inorgan. Chim. Acta 125: 151-158.
Uemori et al., 1986, "Cooperative Dioxygen Binding to the Bi-bridged Dimeric Porphyrinatocobolt(II) Complexes," Inorgan. Chim. Acta. 124: 153-160.
Vorobei et al., 1986, "Search for Photosensitive Agents Specifically Binding with Serum Albumin," Biofizika 31: 757-759. (English Abstract).
Bajdor et al., 1984, "Resonance Raman Studies of O.sub.2 Stretching Vibrations in Oxygen Adducts of Cobalt Porphyrins. The Importance of Vibrational Coupling," J. Am. Chem. Soc. 106: 7741-7747.
Chu and Williams, 1984, "Kinetic Studies on the Reduction of Iron(III)Deuteroporphyrin-Human Serum Albumin Complex with Dithionite Ion," Arch. Biochem. Biophys. 294: 129-137.
Suslick et al., 1984, "Influence of CO and O2 to Iron(II) Porphyrins," J. Am. Chem. Soc. 106: 4522-4525.
Traylor et al., 1984, "Model Compound Studies Related to Peroxidases. Mechanisms of Reactions of Hemins with Peracids," J. Am. Chem. Soc. 106: 755-764.
Baldwin, 1983, "Recent Researches Towards Oxygen Carrying Chelates as Blood Substitutes," Advances in Blood Sub. Res., pp. 149-155.
Chu and Williams, 1983, "The Kinetic Studies on the Reduction of Iron(III)-Porphyrin-HSA Complexes," 74th Annual Meeting of the American Society of Biological Chemists, San Francisco, Calif., USA, Jun. 5-9, Fed. Proc. 42: 2071 (Absract No. 1837).
Herron et al., 1983, "Synthesis and Characterization of Some Reversible Iron(II) Dioxygen Carriers of Lacunar Macrobicyclic Ligands and Their Reactivities with Dioxygen," J. Am. Chem. Soc. 105: 6585-6596.
Imai et al., 1983, "Synthesis and Effectively Reversible Oxgenation of Some Picket Fence Type Porphyrinatocobalt(II) Complexes,"Synth. React. Inorg. Met.-Org. Chem 13: 761-780.
Moehring et al., 1983, "Heterogeneity of Albumin as Detected by its Interactions with Deuteroporphyrin IX," Biochemistry 22: 3381-3386.
Brown and Shockley, 1982, "Serum Albumin: Structure and Characterization of Its Ligand Binding Sites," Ligand-Protein Interact, (Wiley, New York, N.Y., Ed. Jost and Griffith) pp. 25-68.
Shigehara et al., 1981, "Oxygenation of Iron(II) Picket-Fence Porphyrin Bound to Amphiphilic Block Copolymer in Water," Macromol. 14:1153-1161.
Adams and Berman, 1980, "Kinetics and Mechanism of the Interaction Between Human Serum Albumin and Monomeric Haemin," Biochem. J. 191: 95-102.
Jameson et al., 1980, "Models for the Active Site of Oxygen-Binding Hemoproteins. Dioxygen Binding Properties and the Structures of (2-Methylimidazole)-meso-tetra-(.alpha.,.alpha.,.alpha.,.alpha.-o-pivalami dophenyl)porphyrinatoiron(II)-Ethanol and its Dioxygen Adduct," J. Am. Chem. Soc. 102: 3224-3237.
Traylor et al., 1980, "Cyclophane Hemes. 3. Magnitudes of Distal Side Steric Effects in Hemes and Hemoproteins," J. Am. Chem. Soc. 102: 5939-5941.
Collier et al., 1979, "Studies on Haemin in Dimethyl Sulphoxide.Water Mixtures," Biochem. J. 179: 281-289.
Collman et al., 1979, "Carbon Monoxide Binding to Iron Porphyrins," Proc. Natl. Acad. Sci. 76: 6035-6039.
Janado et al., 1979, "Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis of Bovine Serum Albumin Oligomers Produced by Lipid Peroxidation," J. Biochem. 86: 177-182.
Collman et al., 1978, "Model Compounds for the T State of Hemoglobin," Proc. Natl. Acad. Sci. 75: 564-568.
Collman et al., 1978, "Oxygen Binding to Cobalt Porphyrins," J. Am. Chem. Soc. 100: 2761-2766.
Hrkal et al., 1978, "Haeme Binding to Human Serum Albumin and to the Three Large Cyanogen Bromide Albumin Fragments," Int. J. Biochem. 9:349-355.
Chang and Traylor, 1975, "Kinetics of Oxygen and Carbon Monoxide Binding to Synthetic Analogs of the Myoglobin and Hemoglobin Active Sites," Proc. Natl. Acad. Soc. 72: 1166-1170.
Collman et al., 1975, "Oxygen Binding to Iron Porphyrins," J. Am. Chem. Soc. 97: 7185-7186.
Beaven et al., 1974, "A Spectroscopic Study of the Haemin-Human-Serum-Albumin System," Eur. J. Biochem. 41: 539-546.
Brinigar et al., 1974, "Solvent Effects on Reversible Formation and Oxidative Stability of Heme-Oxygen Complexes," J. Am. Chem. Soc. 96: 5597-5599.
Chang and Traylor, 1973, "Solution Behavior of a Synthetic Myoglobin Active Site," J. Am. Chem. Soc. 95: 5810-5811.
Chang and Traylor, 1973, "Proximal Base Influence on the Binding of Oxygen and Carbon Monoxide to Heme," J. Am. Chem. Soc. 95: 8477-8479.
Collman et al., 1973, "Reversible Oxygen Adduct Formation in Ferrous Complexes Derived from a Picket Fence Porphyrin. A Model for Oxymyoglobin, " J. Am. Chem. Soc. 95: 7868-7870.
Baur, 1969, "The Evolution of Methaemalbumin," Comp. Biochem. Physiol. 30: 657-664.
Van Nostrand Reinhold, 1984, Encyclopedia Of Chemistry 4th Ed., pp. 134-141.
Tuschida et al., 1983, "Water Soluble Polymer-Bound Iron-Porphyrins and Their Oxygen Binding Ability," J. Pharm. Dyn. 6:s-9.
Busch, D., 1982, "Chelate Compounds as Components of Acellular, Oxygen-Delivering, Resuscitation Fluids," Critical Care Medicine, 10(4):246-253.
Jones et al., 1979, "Synthetic Oxygen Carriers Related to Biological Systems" Chemical Reviews 79(2): 139-179.
Collman et al., 1976, "Nature of O.sub.2 and CO binding to metalloporphyrins and heme prot

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