Human serpin polypeptides

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C536S023100, C536S023500, C435S252300, C435S325000, C435S320100, C530S350000

Reexamination Certificate

active

07132264

ABSTRACT:
This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin polypeptide activities.

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Hillier, L. et al., GenBank Database Accession No. AA242969, Nov. 27, 1996.
Schick C. et al., “Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis”,Biochemistry37(15): 5258-5266, Apr. 14, 1998.
Silverman G. A. et al., “SCCA1 and SCCA2 are proteinase inhibitors that map to the serpin cluster at 18q21.3”,Tumour Biol19(6): 480-487, Nov.-Dec. 1998.
Spring P. et al., “Identification and cDNA cloning ofheadpin, a novel differentially expressed serpin that maps to chromosome 18q”,Biochem Biophys Res Comm264: 299-304, Oct. 14, 1999.
Carninci and Hayashizaki (Reference 1), Carninci et al. (Reference 2), The RIKEN Genome Exploration Research Group Phaese II Team and FANTOM Consortium (Reference 3), and Adachi J. et al. (Reference 4), GenBank Database Accession No. AK009018, Feb. 8, 2001.
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Askew, Y. S. et al., “SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases”,J Biol Chem276(52): 49320-49330, Dec. 28, 2001.

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