Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1997-05-07
1999-01-12
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435216, 435 691, 4352523, 4353201, 536 232, 424 9464, C12N 964, C12N 1557, C12N 1563, A61K 3848
Patent
active
058587586
ABSTRACT:
The present invention provides a human serine protease precursor (HSPP) and polynucleotides which encode HSPP. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HSPP.
REFERENCES:
patent: 5447914 (1995-09-01), Travis et al.
Dahl, C. A., et al., Human Genetics, vol. 84, "Isolation of cDNA clone encoding a novel form of a granzyme B from human NK cells and mapping to chromosome 14", pp. 465-470, 1990.
Klien, J. L., et al., Tissue Antigens, vol. 35, "Characterization of a novel, human cytotoxid lymphocyte-specific serine protease cDNA clone (CSP-C)", pp. 220-228, 1990.
Haddad, P., et al., International Immunology, vol. 3, "Structure and evolutionalry origin of the human granzyme H gene", pp. 57-66, 1991.
Zunino, S.J. et al., "RNKP-1, A Novel Natural Killer-Associated Serine Protease Gene Cloned From RNK-16 Cytotoxic Lymphocytes," J. Immunol., 144: 2001-2009 (1990) (GI 206689) (GI 206690).
Sayers, T.J. et al., "Purification and Cloning of a Novel Serine Protease, RNK-Tryp-2, from the Granules of a Rat NK Cell Leukemia", J. Immunol., 152: 2289-2297 (1994).
Trapani, J.A. et al., "Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes", Proc. Natl. Acad. Sci., 85: 6924-6928 (1988).
Caputo, A. et al., "Nucleotide Sequence and Genomic Organization of a Human T Lymphocyte Serine Protease Gene", J.Immunol., 145: 737-744 (1990) (GI 306682) (GI 825611).
von Heijne, G., "A new method for predicting signal cleavage sites", Nuc. Acid. Res., 14: 4683-4690 (1986).
Caputo, A. et al., (Direct Submission), GenBank Sequence Database (Accession M38193), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 306682) (GI 825611) (1995).
Corley Neil C.
Hillman Jennifer L.
Shah Purvi
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Mohan-Peterson Sheela
Moore William W.
Wax Robert A.
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