Human RNA-binding protein

Details Human RNA-binding protein Human RNA-binding protein

1996-11-26

1999-10-05

Guzo, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 4353201, 435325, 435366, 435 911, 435 912, 435 914, 536 231, 536 235, 536 243, 536 2431, C12Q 168, C12N 1585, C12P 2102, C07H 2104

Patent

active

059622261

ABSTRACT:
The present invention provides a human RNA bind-protein (HRNABP) and polynucleotides which identify and encode HRNABP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HRNABP and a method for producing HRNABP. The invention also provides for antagonists or antibodies specifically binding HRNABP, and their use, in the prevention and treatment of diseases associated with expression of HRNABP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HRNABP for the treatment of diseases associated with the expression of HRNABP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HRNABP.

REFERENCES:
Hillier, L. et al.: "The WashU-MerCk EST project--zd71g04.sl Soares fetal heart NbHH19W Homo sapiens cDNA clone 346134" EMBL Database Entry HS753361; Accession Number W72753, Jun. 20, 1996, XP002060417 see the reverse sequence.
Hillier, L. et al.: "The WashU-Merck EST project--yr26f07.r1 Homo sapiens cDNA clone 206437 5'" EMBL Database Entry HS613214; Accession Number H63613, Oct. 12, 1995, XP002060418 see abstract.
Hillier, L. et al.: "The WashU-Merck EST project--y66e09.rl Homo sapiens cDNA clone 257224 5'" EMBL Database Entry HS858283; Accession Number N39858, Jan. 26, 1996, XP002060419 see abstract.
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Castiglia et al., "PIPPin, a Putative RNA-Binding Protein Specifically Expressed in the Rat Brain," Biochem. Biophys. Res. Comm. 218:390-394 (1996).

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