Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1997-06-02
1999-02-02
Hendricks, Keith D.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
435199, 4353201, 4352523, 435419, 435 6, 435325, 536 232, C12N 922, C12N 1555, A61K 3847
Patent
active
058661190
ABSTRACT:
This invention relates to nucleic acid and amino acid sequences of a new human ribonuclease and to the use of these sequences in the diagnosis, prevention and treatment of inflammation and disorders associated with cell proliferation and apoptosis.
REFERENCES:
Laccetti, P. et al., "In vivo and in Vitro Growth-inhibitory Effect of Bovine Seminal Ribonuclease on a System of Rat Thyroid Epithelial Transformed Cells and Tumors" Cancer Res. (1992) 52:4582-4586.
Youle, R.J. et al., "RNase inhibition of human immunodeficiency virus infection of H9 cells" Proc.Natl.Acad.Sci.USA (1994) 91:6012-6016.
Mikulski, S.M. et al., "Striking Increase of Survival of Mice Bearing M109 Madison Carcinoma Treated with a Novel Protein from Amphibian Embryos" J.Natl.Cancer Inst. (1990) 82:151-153.
Wu, Y. et al., "A Cytotoxic Ribonuclease" J.Biol.Chem. (1993) 268:10686-10693.
Moroianu, J. and Riordan, J.F. "Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity" Proc.Natl.Acad.Sci.USA (1994) 91:1677-1681.
Beintema, J.J. et al., "Amino Acid Squence of the Nonsecretory Ribonuclease of Human Urine." Biochem. (1988) 27:4530-4538.
Ackerman, S.J. "Characterization and Functions of Eosinophil Granule Proteins" Eosinophils:Biological and Clinical Aspects, CRC Press, Boca Raton, FL, pp. 33-74.
Rosenberg, H.F. and Dyer, K.D. "Molecular cloning and characterization of a novel human ribonuclease (Rnase k6) : increasing diversity in the enlarging ribonuclease gene family." Nucl.Acids Res. (1996) 24:3507-3513. (GI 1513101; GI 1513102).
Rosenberg, H.F. and Dyer, K.D. (GI 1513101), GenBank Sequence Database (Accession U64998), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. (GI 1513102).
Rosenberg, H.G. and Dyer, K.D. "Eosinophil Cationic Protein and Eosinophil-derived Neurotoxin." J.Biol.Chem. (1995) 270:21539-21544.
Bandman Olga
Corley Neil C.
Lal Preeti
Billings Lucy J.
Hendricks Keith D.
Incyte Pharmaceuticals Inc.
Mohan-Peterson Sheela
LandOfFree
Human ribonuclease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human ribonuclease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human ribonuclease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1114555