Human retinoid binding protein

Details Human retinoid binding protein Human retinoid binding protein

1999-01-22

2000-04-18

Feisee, Lila

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

514 2, 435 691, C07K 1400, C07K 14435, A61K 3817, C07H 2104

Patent

active

060516925

ABSTRACT:
The present invention provides a human retinoid binding protein (Hu-RBP) and polynucleotides which identify and encode Hu-RBP. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides methods for the prevention and treatment of diseases associated with expression of Hu-RBP, as well as diagnostic assays.

REFERENCES:
patent: 5654137 (1997-08-01), Astrom et al.
Veerkamp, J.H., et al., "Structural and functional features of different types of cytoplasmic fatty acid-binding proteins", Biochim Biophys Acta, 1081(1): 1-24 (1991).
Ong, D.E., "Cellular Retinoid-Binding Proteins", Arch Dermatol, 123: 1693a-1695a (1987).
Napoli, J.L., "Retinoic acid biosynthesis and metabolism", The FASEB Journal, 10: 993-1001 (1996).
Levin, M.S., et al., "Comparison of the tissue-specific expression and developmental regulation of two closely linked rodent genes encoding cytosolic retinol-binding proteins", J Biol Chem, 262(15): 7118-7124 (1987).
Colantuoni, V., et al., "Cloning and Sequencing of a Full Length cDNA Corresponding to Human Cellular Retinol-Binding Protein", Biochemical and Biophysical Research Communications, 130(1): 431-439 (1985). (GI 190948).
Perozzi, G., et al., "Expression of differentiated functions in the developing porcine small intestine", J. Nutr Biochem, 4: 699-705 (1993). (GI 455523).
Loughney, A.D., et al., "Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle", Human Reproduction, 10(5): 1297-1304 (1995). (GI 535390).
Newcomer, M.E., "Retinoid-binding proteins: structural determinants important for function", FASEB J, 9: 229-239 (1995).
Breitman, T.R., et al., "Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid", Proc Natl Acad Sci USA, 77(5): 2936-2940 (1980).
Fuchs, E., et al., "Regulation of terminal differentiation of cultured human keratinocytes by vitamin A", Cell, 25: 617-625 (1981).
Omenn, G.S., et al., "Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease", N. Engl. J. Med., 334(18): 1150-1155 (1996).
Lotan, R., "Retinoids in cancer chemoprevention", The FASEB Journal, 10: 1031-1039 (1996).
Boylan, J.F., et al., "Overexpression of the cellular retinoic acid binding protein-I (CRABP-I) results in a reduction in differentiation-specific gene expression in F9 teratocarcinoma cells", J Cell Biol, 112(5): 965-979 (1991).
Orfanos, C.E., et al., "Current Use and Future Potential Role of Retinoids in Dermatology", Drugs,53(3): 358-388 (1997).
Rosewicz, S., et al., "Retinoids: Effects on Growth, Differentiation, and Nuclear Receptor Expression in Human Pancreatic Carcinoma Cell Lines", Gastroenterology, 109(5): 1646-1660 (1995).
La Vecchia, C., et al., "Adverse effects of preventive therapy in humans", IARC Sci Publ, 139: 135-152 (1996).
Berkow, R., et al., The Merck Manual of Diagnosis and Therapy, Merck & Co., Rahway N.J. 959-960 (1992).
Kane, C.D., et al., "A simple assay for intracellular lipid-binding proteins using displacement of 1-anilinonapththalene 8-sulfonic acid", Anal Biochem, 233: 197-204 (1996).
Perozzi, G., et al., (GI 455523) GenBank Sequence Database (Accession X77639), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849.
Perozzi, G., et al., (GI 455522) GenBank Sequence Database (Accession X77639), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849.
Levin, M.S., et al., (GI 203584) GenBank Sequence Database (Accession M19257), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849.
Levin, M.S., et al., (GI 203583) GenBank Sequence Database (Accession M19257), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849.
Loughney, A.D., et al., (GI 535390) GenBank Sequence Database (Accession U13831), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849.
Loughney, A.D., et al., (GI 535389) GenBank Sequence Database (Accession U13831), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849.
Colantuoni, V., et al., (GI 190948) GenBank Sequence Database (Accession M11433), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849.
Colantuoni, V., et al., (GI 190947) GenBank Sequence Database (Accession M11433), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849.
Database EMBL, Entry R54U022:AA888151, Accession No. AA888151, XP002072642, Apr. 2, 1998.
Database EMBL, Entry EMEST5:HS1298033, Accession No. AA502122, XP002072643, Jul. 4, 1997.
Database EMBL, Entry EMEST5:HS1275705, Accession No. AA484284, XP002072644, Jun. 24, 1997.
Wallace, B., et al., "Oligonucleotide Probes for the Screening of Recombinant DNA Libraries", Methods Enzymol, 152: 432-442 (1987).
Wei, L.N., et al., "Cellular Retinoic Acid- and Cellular Retinol- Binding Proteins", Molecular Endocrinol, 1(8): 526-534 (1987).

Affiliated with

Also associated with

Rating

Human retinoid binding protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human retinoid binding protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human retinoid binding protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2337125