Human retinoblastoma-related (pRb2/p130) genomic DNA and methods

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 911, 435 912, 435 915, 536 231, 536 241, 536 243, 536 2431, 536 2433, C12Q 168, C12P 1934, C07H 2104

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058076816

ABSTRACT:
The invention provides methods for the detection of mutations and polymorphisms in the pRb2/p130 gene, which may be used to characterize genetic events associated with tumor formation, to trace the parental origin of mutatations, to identify carriers of germline mutations, and to identify individuals with a predisposition to cancer.

REFERENCES:
patent: 5340739 (1994-08-01), Stevens et al.
patent: 5457049 (1995-10-01), Giordano
patent: 5521081 (1996-05-01), Inoaka et al.
patent: 5597694 (1997-01-01), Munroe et al.
patent: 5654170 (1997-08-01), Klinger et al.
Sinnett et al., in Database GenBank, Accession: M87919, Locus: HUMALNES53, NID: g174893, U.S. National Library of Medicine, National Institutes of Health, Apr. 1994.
Thomas et al., "A Polymorphic Dinucleotide Repeat in Instron 1 of the Human Tissue Plasminogen Acivator Gene" Human Molecular Genetics, 1992, vol. 1, No. 2, p. 138.
Slightrom et al., "Nucleotide Sequence Analysis of 77.7 kb of the Human V .beta. T-Cell Receptor Gene Locus: Direct Primer-Walking Using Cosmid Template DNAs", Genomics, 1994, vol. 20, pp. 149-168.
Hirata et al., "Cloning and expression of cDNA for a human thromboyane A.sub.2 receptor", Nature 14 Feb. 1991, vol. 349, pp. 617-620.
Stoppa-Lyonnet et al., "Clusters of intragenic Alu Repeats Predispose the Human C1 Inhibitor Locus to Deleterious Rearrangements", Proc. Natl. Acad. Sci. USA, Feb. 1990, vol. 87, pp. 1551-1555.
Whitehead et al., "Identification of Novel Members of the Serum Amyloid A Protein Superfamily as Constitutive Apolipoproteins of High Density Lipoprotein", J. Biological Chemistry, 25 Feb. 1992, vol. 267, No. 6 pp. 3862-3867.
Wilson et al., "2.2 Mb of contiguous Nucleotide Sequence from Chromosome III of C. elegans", Nature 3 Mar. 1994, vol. 368, pp. 32-38.
Wilson et al., "Human Hypoxanthine-Guanine Phosphoribosyltransferase" J. Biological Chemistry, 25 May 1983, vol. 258, No. 10, pp. 6458-6460.
Vorechovsky et al., "Isolation of cosmid and cDNA clones in the region surrounding the TTK gene at Xq21.3-q22", Genomics, 1994, vol. 21 pp. 517-524.
Zheng et al., "Develoment of 124 sequence-tagged sites and cytogenetic localization of 217 cosmids for human chromosome 10", Genomics, 1994 vol. 22, pp. 55-67.
Lifshitz et al., "bcr Genes and Transcripts", Oncogene 1988, vol. 2, pp. 113-117.
Hannon et al., Genes & Development 7:2378-2391 (1993).
Li et al., Genes & Development 7:2366-2377 (1993).
Cinti et al., Nucleic Acids Research, 21(24):5799-5800 (1993).
Hogg et al., Oncogene 7:1445-1451 (1992).
Hong et al., Proc. Natl. Acad. Sci USA 86:5502-5506 (Jul. 1989).
Harbour et al., Science 241:353-357 (15 Jul. 1988).
Baldi et al., Journal of Cellular Biochemistry 59:402-408 (1995).
Claudio et al., Cancer Research 54:5556-5560 (Nov. 1, 1994).
Sang et al., Molecular and Cellular Differentiation 3(1): 1-29 (1995).
Baldi et al., Proc. Natl. Acad. Sci. USA 93:4629-4632 (May 1996).
Claudio et al., American Association for Cancer Research Proceedings 36:195, #1164 (Mar. 1995).
Mayol et al., Oncogene 8:2561-2566 (1993).

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