Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-03-15
1997-01-07
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4352523, 4353201, 536 235, C12Q 168, C12N 120, C12N 1500, C07H 2104
Patent
active
055915833
ABSTRACT:
Human restrictin proteins and nucleic acid sequences encoding them are provided. Antibodies which recognize human restrictin in human brain are disclosed. In the human brain, restrictin occurs as two major polypeptides of 180 and 160 kD located in fiber tracts. These polypeptides are similar to those seen in rat brain. Surprisingly, restrictin has also been found in the peripheral nerves of rats and humans. The antibodies also detect a 170 kD polypeptide in MATRIGEL, an extracellular matrix product of rat EHS sarcoma cells widely used as a tissue culture substrate. Monoclonal antibodies to human restrictin and assays using the human restrictin protein, antibodies and DNA sequences are also provided.
REFERENCES:
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M. Schachner, et al. "The Perplexiing Multifunctionality of Janusin, a Tenascin-Related Molecule" Perp. Dev. Neurobiol. 2:33-41 (1994).
R. Chiquet-Ehrismann, et al. "The Tenascin Gene Family" Perp. Dev. Neurobiol. 2:3-7 (1994).
F. G. Rathjen, et al. "Restrictin: a chick neural extracellular matrix protein involved in cell attachment co-purifies with the cell recognition molecule F11" Development 113:151-164 (1991).
A. Lochter, et al. "The Extracellular Matrix Molecule Janusin Regulates Neuronal Morphology in a Substrate-and Culture Time-dependent Manner" Euro. J. Neurosci. 6:597-606 (1994).
P. Pesheva, et al. "Tenascin-R (J1 160/180) inhibits fibronectin-mediated cell adhesion -functional relatedness to tenascin-C" J. Cell Sci. 107:2323-2333 (1994).
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Ackley Rhonda L.
Hemperly John J.
Reid Robert A.
Becton Dickinson and Company
Fugit Donna R.
Hobbs Lisa J.
Wax Robert A.
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