Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-04-20
1995-09-19
Warden, Jill
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, A61K 3816, A61K 3817
Patent
active
054515726
ABSTRACT:
A pharmaceutical composition is provided wherein human relaxin is formulated at an acidic pH of about 4 to less than about 7. The composition, useful for effecting parturition and inhibiting premature delivery, includes a buffer capable of maintaining the pH of the composition within a desired range, and may also include an agent to make the composition isotonic, and a stabilizing agent, if necessary. A specific example is human relaxin formulated in a citrate buffer, pH about 5.0, in the presence of sodium chloride, at an ionic strength of about 0.15 .mu..
REFERENCES:
patent: 2964448 (1960-12-01), Anschel
patent: 3003117 (1961-10-01), Beiler
patent: 4267101 (1981-05-01), Bigazzi
patent: 4624804 (1986-11-01), Voelter et al.
patent: 4758516 (1988-07-01), Hudson et al.
Remington's Pharmaceutical Sciences, vol. 15, Dwight L. Deardorff, "Isotonic Solutions", pp. 1405-1418 (1975).
Eduard Eichner, et al. "Relaxin, the Third Ovarian Hormone: Its Experimental Use in Women", (1956), pp. 1035-1048 vol. 71, No. 5 Am. J. Obst. & Gynecology.
R. K. Eldridge, et al., "Rabbit Placental Relaxin: Purification and Immunohistochemical Localization", (1985) pp. 2512-2519 vol. 117, No. 6, Endocrinology.
P. A. Fields, et al., "Purification of Relaxin From the Placenta of the Rabbit", (1982) pp. 75-86 380 Annals New York Acadamy of Sciences.
Alastair H. MacLennan, et al. "Ripening of the Human Cervix and Induction of Labour with Purified Porcine Relaxin", (1980) pp. 220-223, The Lancet.
Alastair H. MacLennan, et al., "Cervical Ripening with Combinations of Vaginal Prostaglandin F.sub.2 alpha Estradiol, and Relaxin", Nov. 1981, pp. 601-604, vol. 58, No. 5, Obstetrics and Gynecology.
A. H. MacLennan, et al., "The Effect of Procine Relaxin Vaginally Applied at Human Embryo Transfer in an In Vitro Fertilization Programme", (1985) pp. 68-71, 25:68 Aust. and N.Z. Journal of Obstetrics and Gynaecology.
Alastair H. MacLennan, et al., "Ripening of the Human Cervix and Induction of Labor with Intracervical Purified Porcine Relaxin" (1986) pp. 598-601, vol. 68, No. 5, Obstetrics & Gynecology.
O. David Sherwood, "Relaxin", (1988), pp. 585-673, The Physiology of Reproduction, edited by E. Knobil and J. Neill et al. Raven Press, Ltd., New York.
Birnberg and Abitol, "Refined Relaxin and Length of Labor", (1957) pp. 366-370, vol. 10, No. 4, Obstetrics and Gynecology.
Cipolla David C.
Nguyen Tue H.
Shire Steven J.
Genentech Inc.
Halluin Albert P.
Salata Carol A.
Warden Jill
LandOfFree
Human relaxin formulation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human relaxin formulation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human relaxin formulation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1828223