Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1983-12-20
1985-05-21
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Lymphokine
260112R, 2601125R, 435 68, 4351723, 435317, 435253, 514 2, 514 8, 514 12, A61K 4502, A61K 3702, C07C10352, C07G 700, C12P 2106, C12N 1500
Patent
active
045185840
ABSTRACT:
Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These muteins are made via bacterial expression of mutant genes that encode the muteins that have been synthesized from the genes for the parent proteins by oligonucleotide-directed mutagenesis.
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Lin Leo S.
Lu Shi-da Y.
Mark David F.
Cetus Corporation
Ciotti Thomas E.
Halluin Albert P.
Hazel Blondel
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