Human recombinant interleukin-2 muteins

Details Human recombinant interleukin-2 muteins Human recombinant interleukin-2 muteins

1989-07-26

1991-07-30

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Lymphokine

424 852, 424 856, 435 6951, 435 6952, 4351323, 514 2, 514 8, 514 12, 530351, 530809, A61K 4500, A61K 3702, C07K 1506, C12P 2106

Patent

active

RE0336530

ABSTRACT:
Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These muteins are made via bacterial expression of mutant genes that encode the muteins that have been synthesized from the genes for the parent proteins by oligonucleotide-directed mutagenesis.

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