Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1984-09-28
1986-05-13
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Lymphokine
4351723, 435 68, 530351, A61K 4502, C07K 1300, C07K 1526, C12P 2100
Patent
active
045885850
ABSTRACT:
Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These muteins are made via bacterial expression of mutant genes that encode the muteins that have been synthesized from the genes for the parent proteins by oligonucleotide-directed mutagenesis.
REFERENCES:
patent: 4414150 (1983-11-01), Goeddel
Shepard, H. M., et al., Nature, 294, 563-565, 1981.
Shiroishi, T., et al., Proc. Natl. Acad. Sci., vol. 81, pp. 7544-7548, 1984.
Glossary of Genetics and Cytogenetics, 4th ed., p. 381, Springer-Verlag (1976).
Taniguchi, T. et al., Gene (1980) 10:11-15.
Taniguchi, T. et al., Nature (1980) 285:547-549.
Lathe, R. F. and Lecocq, J. P., Genetic Engineering Academic Press (1983) pp. 31-50.
Smith, M. and Gillam, S., Genetic Engineering Principles and Methods, Plenum Press (1981) 3:1-32.
Goeddel, D. V. et al., Nucleic Acids Research (1980), 8 (18) 4057-4074.
Taniguchi, T. et al., PNAS (1980), 77 (9) 5230-5233.
Allen G. et al., Nature (1980) 287, 408-410.
Levy, W. et al., PNAS (1981), 78 (10) 6186-6190.
Knight, S. E. et al., Journal of Interferon Research, (1982), 2 (3) 421-429.
Lin Leo S.
Lu Shi-Da Yu
Mark David F.
Cetus Corporation
Ciotti Thomas E.
Halluin Albert P.
Hazel Blondel
Lauder Leona L.
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