Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2005-11-17
2009-08-18
Saoud, Christine J (Department: 1647)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S070100, C530S351000
Reexamination Certificate
active
07575894
ABSTRACT:
The invention relates to variants of recombinant human beta interferon and to a method for the production thereof, wherein at least one of the following amino acids Leu(5), Phe(8), Phe(15), Leu(47), Phe(50), Leu(106), Phe(111), Leu(116), Leu(120) and Phe(156) is exchanged with hydrophilic amino acid with a hydroxy group, specially serine, tyrosine or threonine, resulting in enhanced hydrophilic property of the protein surface.
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Luck et al., Single Amino Acid Substitutions in Recombinant Bovine Prolactin That Markedly Reduce Its Mitogenic Activity in Nb2 Cell Culture (1991), Molecular Endocrinology , vol. 5(12), pp. 1880-1886.
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Shepard et al., “A single amino acid change in IFN-β, abolishes its antiviral activity”, Nature, vol. 294, Dec. 10, 1981, pp. 563-565.
Gibson et al., “Novel Single Nucleotide Polymorphisms in the Distal IL-10 Promotor Affect IL-10 Production and Enhance the Risk of Systemic Lupus Erythematosus”, The Journal of Immunology, 2001, vol. 166, pp. 3915-3922.
Luck, et al., “Single Amino Acid Substitutions in Recombinant Bovine Prolactin That Markedly Reduce Its Mitogenic Activity in Nb2 Cell Cultures”, Molecular Endocrinology, 1991, vol. 5(12), pp. 1880-1886.
Otto Bernd
Schneider-Fresenius Christian
Waschütza Gero
Barnes & Thornburg LLP
Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung
Saoud Christine J
Seharaseyon Jegatheesan
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