Human recombinant beta-interferon with improved solubility

Details Human recombinant beta-interferon with improved solubility Human recombinant beta-interferon with improved solubility

2006-05-30

2006-05-30

Andres, Janet L. (Department: 1647)

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

C424S085400, C530S351000, C435S069510

Reexamination Certificate

active

07052687

ABSTRACT:
The invention relates to variants of recombinant human beta interferon and to a method for the production thereof, wherein at least one of the following amino acids Leu (5), Phe(8), Phe(15), Leu(47), Phe(50), Leu(106), Phe(111), Leu(116), Leu(120) and Phe(156) are exchanged with hydrophilic amino acid with a hydroxy group, specially serine, tyrosine or threonine, resulting in enhanced hydrophilic property of the protein surface.

REFERENCES:
patent: 4588585 (1986-05-01), Mark et al.
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 0 163 993 (1985-05-01), None
Luck et al., Molecular Endocrinology 1991, vol. 5(12): pp. 1880-1886, esp. p. 1881, table 1.
Gibson et al., J Immunol. 2001, vol. 166(6): pp. 3915-3922, esp. p. 3915.
Shepard et al., Nature. 1981, vol. 294(5841): pp. 563-565 (esp. p. 563: Title and Table 1).
Kruse et al. Embo J., 1993, vol. 12, No. 13, pp. 5121-5129.

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