Human receptor tyrosine kinase, KDR

Details Human receptor tyrosine kinase, KDR Human receptor tyrosine kinase, KDR

2005-01-11

2005-01-11

Kemmerer, Elizabeth (Department: 1646)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S069100, C435S069700, C435S183000, C435S252300, C435S254110, C530S350000, C536S023500, C536S023400

Reexamination Certificate

active

06841382

ABSTRACT:
An isolated nucleic acid molecule encoding a novel human receptor type tyrosine kinase gene, KDR, is disclosed. The isolation of this KDR cDNA sequence results in disclosure of purified forms of human KDR protein, recombinant vectors and recombinant hosts which express human KDR.

REFERENCES:
patent: 5240848 (1993-08-01), Keck et al.
patent: 5332671 (1994-07-01), Ferrara et al.
patent: 5766860 (1998-06-01), Terman et al.
patent: 5861301 (1999-01-01), Terman et al.
patent: 0 506 477 (1992-03-01), None
patent: WO 9214748 (1992-09-01), None
patent: WO 9214748 (1992-09-01), None
patent: WO 9411499 (1994-05-01), None
Ferrara, N. et al; The Vascular Endothelial Growth Factor Family of Polypeptides; Journal of Cellular Biochemistry, vol. 47; 1991; pp. 211-218.
Maglione, D. et al; Two Alternative mRNAs coding for the angiogenic factor, placenta growth factor (PIGF), Are Transcribed from a Single Gene of chromosome 14; Oncogene; vol. 8, 1993, p. 925-931.
Hauser, S. et al.; A Heparin-Binding Form of Placenta; Growth Factor (PIGF-2) is Expressed in Human Umbilical Vein Endothelial Cells and in Placenta; Growth Factors; vol. 9, 1993; pp. 259-268.
Grimmond, S. et al; Cloning and Characterization of a Novel Human Gene Related to Vascular Endothelial Growth Factor; Genome Research; vol. 6, 1996; pp. 124-131.
Olofsson, B. et al; Vascular Endothelial Growth Factor B, A Novel Growth Factor for Endothelial cells; Proc. Natl. Acad Sci. USA, vol. 93, 1996; pp. 2576-2581.
Joukov, V. et al; A Novel Vascular Endothelial Growth Factor, VEGF-C is a Ligand for the FLT (VEGFR-3) and KDR (VEGFR-2) Receptor Tyrosine Kinases; The EMBO Journal; vol. 15; No. 2; 1996; pp. 290-298.
Shibuya, M. et al. Nucleotide Sequence and Expression of a Novel Human Receptor-Type Tyrosine Kinase Gene (FLT) closely Related to the fms Family; Oncogene; vol. 5, 1990, pp. 519-524.
Pajusola, K. et al, FLT4 Receptor Tyrosine Kinase Contains Seven Immunoglobin-like Loops and Is Expressed in Multiple Human Tissues and Cell Lines; Cancer Research; vol. 52, 5738-5743.
Terman, B.I. et al; Identification of a New Endothelial Cell Growth Factor Receptor Tyrosine Kinase; Oncogene; vol. 6, 1991, pp. 1677-1683.
Terman, B.J. et al; Identification of the KDR Tyrosine Kinase as a Receptor for Vascular Endothelial Cell Growth Factor, Biochemical & Biophysical Research Communications; vol. 187, No. 3; 1992, pp. 1579-1586.
Rockwell et al. ‘In Vitro Neutralization . . . Monoclonal Antibody’, Mol. Cell Differ., vol. 3(1), pp. 91-109 (1995).

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