Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Reexamination Certificate
2005-01-11
2005-01-11
Spector, Lorraine (Department: 1646)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
C435S069100, C435S007100, C435S007800, C530S350000, C536S023200, C536S023400, C536S023500
Reexamination Certificate
active
06841367
ABSTRACT:
An isolated nucleic acid molecule encoding a novel human receptor type tyrosine kinase gene, KDR, is disclosed. The isolation of this KDR cDNA sequence results in disclosure of purified forms of human KDR protein, recombinant vectors and recombinant hosts which express human KDR.
REFERENCES:
patent: 5240848 (1993-08-01), Keck et al.
patent: 5332671 (1994-07-01), Ferrara et al.
patent: 5766860 (1998-06-01), Terman et al.
patent: 5861301 (1999-01-01), Terman et al.
patent: 6177401 (2001-01-01), Ullrich et al.
patent: 0 506 477 (1992-03-01), None
patent: WO 9214748 (1992-09-01), None
patent: WO 9411499 (1994-05-01), None
Darnay et al., Physical and functional association of a serine-tyrosine protein kinase to the cytoplasmic domain of p80 form of the human tumor necrosis factor receptor in human histocytic lymphoma U-937 cells, J. Biol. Chem., 269(31):19687-90, Aug. 5, 1994.*
Rockwell et al., In vitro neutralization of vascular endothelial growth factor activation of Flk-1 by a monoclonal antibody, Mol. Cell. Diff., 3(1):91-109, 1995.*
Nilsson et al., Fusion proteins in biotechnology and structural biology, Curr. Opin. Struct. Biol., 2:569-575, 1992.*
Ferrara, N. et al; The Vascular Endothelial Growth Factor Family of Polypeptides; Journal of Cellular Biochemistry, vol. 47; 1991; pp. 211-218.
Maglione, D. et al; Two Alternative mRNAs coding for the angiogenic factor, placenta growth factor (PIGF), Are Transcribed from a Single Gene of chromosome 14; Oncogene; vol. 8, 1993, p. 925-931.
Hauser, S. et al.; A Heparin-Binding Form of Placenta; Growth Factor (PIGF-2) is Expressed in Human Umbilical Vein Endothelial Cells and in Placenta; Growth Factors; vol. 9, 1993; pp. 259-268.
Grimmond, S. et al; Cloning and Characterization of a Novel Human Gene Related to Vascular Endothelial Growth Factor; Genome Research; vol. 6, 1996; pp. 124-131.
Olofsson, B. et al; Vascular Endothelial Growth Factor B, A Novel Growth Factor for Endothelial cells; Proc. Natl. Acad Sci. USA, vol. 93, 1996; pp. 2576-2581.
Joukov, V. et al; A Novel Vascular Endothelial Growth Factor, VEGF-C is a Ligand for the FLT (VEGFR-3) and KDR (VEGFR-2) Receptor Tyrosine Kinases; The EMBO Journal; vol. 15; No. 2; 1996; pp. 290-298.
Shibuya, M. et al. Nucleotide Sequence and Expression of a Novel Human Receptor-Type Tyrosine Kinase Gene (FLT) closely Related to the fms Family; Oncogene; vol. 5, 1990, pp. 519-524.
Pajusola, K. et al, FLT4 Receptor Tyrosine Kinase Contains Seven Immuneogloblin-like Loops and Is Expressed in Multiple Human Tissues and Cell Lines; Cancer Research; vol. 52, 5738-5743, Oct. 1992.
Terman, B.I. et al; Identification of a New Endothelial Cell Growth Factor Receptor Tyrosine Kinase; Oncogene; vol. 6, 1991, pp. 1677-1683.
Terman B.I. et al; Identification of the KDR Tyrosine Kinase as a Receptor for Vascular Endothelial Cell Growth Factor, Biochemical & Biophysical Research Communications; vol. 187, No. 3; 1992, pp. 1579-1586.
Kendall Richard L.
Mao Xianzhi
Tebben Andrew
Thomas Kenneth A.
Kaufman Claire M.
Merck & Co. , Inc.
Spector Lorraine
Tribble Jack L.
Xu Yang
LandOfFree
Human receptor tyrosine kinase, KDR does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human receptor tyrosine kinase, KDR, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human receptor tyrosine kinase, KDR will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3380169