Human receptor proteins; related reagents and methods

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S387300, C530S388100, C530S388150

Reexamination Certificate

active

10975909

ABSTRACT:
Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.

REFERENCES:
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 5853977 (1998-12-01), Dalie et al.
patent: WO98/02557 (1998-01-01), None
patent: WO98/50547 (1998-11-01), None
patent: WO99/20756 (1999-04-01), None
patent: WO 00/24776 (2000-05-01), None
patent: WO 01/62922 (2001-08-01), None
DataBase: A-Geneseq, Accession No. AAW86361, Ruben SM [WO9850547, Mar. 15, 1998].
DataBase: PIR-80, Accession No. O00206, Medzhitove et al Jul. 1997.
Golenbock et al, Nature Immunology, Apr. 2001. vol. 2, No. 4, pp. 286-288.
M.D. Adams, et al.,GenBank, Accession No. AA381849, Apr. 21, 1997. Definition: “EST94973 Activated T-cells IHomo sapienscDNA 5′ and similar to similar toH. sapienshypothetical protein (GP:D13637—), mRNA sequence.”
Mark D. Adams, et al.,Nature, 377:3-17, Sep. 28, 1995, “Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence”.
James W. Baumgartner, et al.,J. Biological Chemistry, 269(46):29094-29101, 1994. “The Role of the WSXWS Equivalent Motif in Growth Hormone Receptor Function”.
Marcia P. Belvin, et al.,Annu. Rev. Cell Dev. Biol., 12:393-416, 1996. “A Conserved Signaling Pathway: TheDrosophiliaToll-Dorsal Pathway”.
Irwin M. Chalken and William V. Williams,TIBTECH, 14:369-375, 1996. “Identifying structure-function relationships in four-helix bundle cytokines: towads de novo mimetics design”.
Charles A. Dinarello,Blood, 87(6):2095-2147, Mar. 15, 1996. “Biologic Basis for Interleukin-1 in Disease”.
Charles A. Dinarello,Blood, 77(8):1627-1652, Apr. 15, 1991. “Interleukin-1 and Interleukin-1 Antagonism”.
Charles A. Dinarello,The FASEB Journal, 8:1314-1325, Dec. 1994. “The interleukin-1 family: 10 years of discovery”.
David G. George, et al.,Macromolecular Sequencing and Synthesis Selected Methods and Application, Ch. 12, pp. 127-149, 1988. “Current Methods in Sequence Comparison and Analysis”.
I.R. Gibbons, et al.,Proc. Natl. Acad. Sci. USA, 88:8563-8567, Oct. 1991. “A PCR procedure to determine the sequence of large polypeptides by rapid walking through a cDNA library”.
Thomas J. Gonda and Richard J. D'Andrea,Blood, 89(2):355-369. “Activating Mutations in Cytokine Receptors: Implications for Receptor Function and Role in Disease”.
Gary Hardiman, et al.,Oncogene, 13:2467-2475, 1996. “Modular characterization and molecular analysis of humanMyD88”.
M. Hibi, et al.,GenBank, Accession No. M57230, Jan. 5, 1995. Definition: “Human membrane glycoprotein gp130 mRNA, complete cds.”
L. Hillier, et al.,GenBank, Accession No. AA042999, May 10, 1997. Definition: “zk56c03.r1 Soares—pregnant—uterus—NbHPUHomo sapienscDNA clone IMAGE:486820 5′, mRNA sequence.”
L. Hillier, et al.,GenBank, Accession No. AA707766, Dec. 24, 1997, Definition: “zh24d04.s1 Soares—pineal—gland—N3HPGHomo sapienscDNA clone IMAGE:412999 3′, mRNA sequence.”
L. Hillier, et al.,GenBank, Accession No. AA05049, May 9, 1997. Definition: “zh96c04.r1 Soares—fetal—liver—splean—1NFLS—S1Homo sapienscDNA clone IMAGE:429126 5′, mRNA sequence”.
L. Hillier, et al.,GenBank, Accession No. H48602, Sep. 15, 1995. Definition: “yq80b01.r1 Soares fetal liver spleen 1NFLSHomo sapienscDNA clone IMAGE:202057 5′ similar to SP:TOLL—DROME P08953 Toll Protein ;, mRNA sequence”.
L. Hillier, et al.,GenBank, Accession No. N41021, Jan. 22, 1996. Definition: “yy53b03.s1 Soares—multiple—sclerosis—2NbHMSPHomo sapienscDNA clone IMAGE:277229 3′, mRNA sequence”.
L. Hillier, et al.,GenBank, Accession No. R76150, Jun. 6, 1995. Definition: “yi71d02.r1 Soares placenta Nb2HPHomo sapienscDNA clone IMAGE:144675 5′, mRNA sequence”.
L. Hillier, et al.,GenBank, Accession No. T60365, Feb. 13, 1995. Definition: “yb90h06.r1 Stratagene liver (#937224)Homo sapienscDNA clone IMAGE:78491 5′, mRNA sequence”.
Dan Hultmark,Nature, 367:116-117, Jan. 13, 1994. “Ancient relationships”.
A.D. Larsen,GenBank, Accession No. X55721, Feb. 6, 1991. Definition: “Human mRNA coding for granulocyte colony stimulating factor receptor 25-1.”
Bruno Lemaitre, et al.,Cell, 86:973-983, Sep. 20, 1996. “The Dorsoventral Regulatory Gene Cassettespätzle/Toll/cactusControls the Potent Antifungal Response in Drosophilia Adults”.
Patrick Lemaire and Laurent Kodjabachian,Trends in Genetics, 12(12):525-531, Dec. 1996. “The vertibrate organizer: structure and molecules”.
Mark A. Lemmon and Joseph Schlessinger,TIBS, 19:459-463, Nov. 1994. “Regulation of signal transduction and signal diversity by receptor oligomerization”.
M. Marra, et al.,GenBank, Accession No. AA266744, Mar. 21, 1997. Definition: “mz93d07.r1 Soares mouse lymph node NbMLN Mus musculus cDNA clone IMAGE:720973 5′, mRNA sequence.”
M. Marra, et al.,GenBank, Accession No. AA288480, Apr. 4, 1997. Definition: “vb16a09.r1 Soares mouse 3NbMS Mus musculus cDNA clone IMAGE:749080 5′, mRNA sequence.”
R. Medzhitov, et al.,GenBank, Accession No. U93091, Nov. 30, 1998. Definition: 'Human Toll protein homolog mRNA, complete cds and LINE-1 reverse transcriptase homolog, pseudogene.
Rusian Medzhitov, et al.,Nature, 388:394-397, Jul. 24, 1997. “A human homologue of the Drosophila Toll protein signals activation of adaptive immunity”.
Donald Morisato & Kathyrn V. Anderson,Annu. Rev. Genetics, 29:371-399, 1995, “Signaling Pathways that Establish the Dorsal-Ventral Pattern of theDrosphilaEmbryo”.
D. Muzny, et al.,GenBank, Accession No. AC003046, AC002362, AC002363, Jan. 6, 1998. Definition: “Homo sapiensXp22 PACs RPC11-263P4 and RPC11-164K3 complete sequence.”
NCI-CGAP,GenBank, Accession No. AA740990, Feb. 7, 1998. Definition: nz05g01.s1 NCI—CGAP—GCBIHomo sapienscDNA clone IMAGE:1286928 3′ similar to TR:Q15399 Q15399 ORF, Complete CDs. ;, mRNA sequence.
NCI-CGAP,GenBank, Accession No. AA741118, Feb. 7, 1998. Definition: “nz04f11.s1 NCI—CGAP—GCBIHomo sapienscDNA clone IMAGE:1286829 3′, mRNA sequence.”
NCI-CGAP,GenBank, Accession No. AA252405, Aug. 13, 1997. Definition: “zs12e09.r1 NCI—CGAP—GCBIHomo sapienscDNA clone IMAGE:685000 5′, mRNA sequence.”
Nobuo Nomura, et al., DNA Research 1:27-35, 1994. “Prediction of the Coding Sequences of Unidentified Human Genes. I. The Codong Sequences of 40 New Genes (KIA A0001-KIA A0040) Deduced by Analysis of Randomly Sampled cDNA Clones from Human Immature Myeloid Cell Line KG-1”.
N. Nomura,GenBank, Accession No. D13637, Jul. 10, 1997. Definition: “Human mRNA for KIAA0012 gene, complete cds.”
Haruki Okamura, et al.,Nature, 378:88-91, Nov. 12, 1995. “Cloning of a new cytokine that induces IFN-□production by T cells”.
K. Okubo,GenBank, Accession No. C01399, Jul. 23, 1996. Definition: “HUMGS0008381 Human adult (K. Okubo)Homo sapienscDNA, mRNA sequence.”
Jay D. Parker, et al.,Nucleic Acids Research, 19(11):3055-3060, Jun. 11, 1991. “Targeted gene walking polymerase chain reaction”.
D.H. Presky, et al.,GenBank, Accession No. U64198, Nov. 26, 1996. Definition: “Human II-12 receptor beta2 mRNA, complete cds.”
Fernando L. Rock, et al.,Proc. Natl. Acad. Sci. USA, 95:588-593, Jan. 1998. “A family of human receptors structurally related toDrosophila

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Human receptor proteins; related reagents and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human receptor proteins; related reagents and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human receptor proteins; related reagents and methods will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3736917

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.