Human ras-related oncogenes unmasked by expression cDNA cloning

Details Human ras-related oncogenes unmasked by expression cDNA cloning Human ras-related oncogenes unmasked by expression cDNA cloning

1994-05-24

1998-08-11

Walsh, Stephen

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 6, 536 232, 536 2431, C12N 916, C12N 1501, C12N 1512, C12Q 168

Patent

active

057926387

ABSTRACT:
The oncogene of the present invention, isolated by expression cloning from a human ovarian cancer is a mutant of TC21. The present invention teaches that ras-related genes not thought to have transforming potential can contribute importantly to cancers which have been refractory to oncogene detection. The present invention teaches that another ras relative gene, R-ras, which was previously reported to lack transforming potential, has transforming capacity as well. Thus, these and other genes similarly related to prototype and activated by analogous mechanisms may be important in the diagnosis and prognosis of certain cancers, as well as be critical in the design of rational approaches to therapy of cancers in which they play a role.

REFERENCES:
patent: 5234839 (1993-08-01), McCormick et al.
Bos. ras oncogenes in human cancer: a review. Cancer Research. vol.49, pp. 4682-4689, Sep. 1, 1989.
Valencia et al. The ras protein family: evolutionary tree and role of conserved amino acids. Biochemistry. vol.30, No.19, pp. 4637-4648, May 14, 1991.
Barbacid. ras genes. Annual Review of Biochemistry. vol. 56, pp. 779-827, 1987.
AA. Chan, et al.; "A human oncogene of the RAS superfamily unmasked by expression cDNA cloning", PNAS USA 91: 7558-7562 (Aug. 1994).
BB. Saez, et al., "Oncogenic activation of human R-ras by point mutations analogous to those of prototype H-ras oncogenes", Oncogene 9(10): 2977-2982 (Oct. 1994).
CC. Cox, et al., "R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells", Oncogene 9(11): 3281-3288 (Nov. 1994).
DD. Carboni, et al., "Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation" Oncogene 10(10): 1905-1913 (May 18, 1995).
D. G. Lowe, et al. "Structure of the Human and Murine R-ras Genes, Novel Genes Closely Related to ras Proto-oncogenes," Cell. vol. 48, pp. 137-148, Jan. 16, 1987.
D. G. Lowe, et al. "Heterologous Expression and Characterization of the Human R-ras Gene Product," Molecular and Cellular Biology, pp. 2845-2856, Aug. 1987.
G. T. Drivas, et al. "Characterization of Four Novel ras-Like Genes Expressed in a Human Teratocarcinoma Cell Line," Molecular and Cellular Biology, pp. 1793-1798, Apr. 1990.
H. B. Muss, et al. "c-erbB-2 Expression and Response to Adjuvant Therapy in Women With Node-Positive Early Breast Cancer," The New England Journal of Medicine, pp. 1260-1266, May 5,1994.
S.M. Graham, et al. "Aberrant Function of the Ras-Related Protein TC21/R-Ras2 Triggers Malignant Transformation, " Molecular and Cellular Biology, pp. 4108-4115, Jun. 1994.

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