Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-05-09
1999-03-16
Campbell, Eggerton A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 231, C12Q 168, C07H 2104
Patent
active
058828621
ABSTRACT:
This invention provides isolated nucleic acids which encode a wildtype and a mutant human homolog of RAD9. This invention also provides purified and mutant wildtype human homologs of RAD9. This invention also provides methods for determining whether a subject has radiosensitivity; for predicting the effect of radiation therapy or chemotherapy on a subject; for detecting whether a subject has a predisposition to cancer; for treating a subject who is radiosensitive and for preventing or treating cancer in a subject who is radiosensitive.
REFERENCES:
al-Khodairy, F. and A.M. Carr (1992) "DNA repair mutants defining G.sub.2 checkpoint pathways in Schizosaccharomyces pombe." Embo J 11: 1343-1350.
Barker, H.M., et al. (1990) "Localization of the gene encoding a type 1 protein phosphatase catalytic subunit to human chromosome band 11q13." Genomics 7: 159-166.
Duyao, M.P., et al. (1995) "Inactivation of the mouse Huntington's disease gene homolog Hdh." Science 269: 407-410.
Enoch, T., et al. (1992) "Fission yeast gene involved in coupling mitosis to completion of DNA replication." Genes Dey 6: 2035-2046.
Griffin, E.F. and H. Harris (1992) "Total inhibition of involucrin synthesis by a novel two-step antisense procedure; further examination of the relationship between differentiation and malignancy in hybrid cells." J. Cell Science 102: 799-805.
Jesudasan, R.A., et al. (1995) "Deletion and translocation of chromosome 11q13 sequences in cervical carcinoma cell lines." Am J Hum Genet 56: 705-715.
Larsson, C., et al. (1988) "Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma." Nature 332: 85-87.
Larsson, C., et al. (1992) "Isolation and mapping of polymorphic cosmid clones used for sublocalization of the multiple endocrine neoplasia type 1 (MEN1) locus." Hum Genet 89: 187-193.
Larsson C., et al. (1994) "Localization and identification of the multiple endocrine neoplasia type 1 disease gene." Endocrinol Metab Clin North Am 23: 67-79.
Lieberman, H.B., et al. (1992) "Molecular cloning and analysis of Schizosaccharomyces pombe rad9, a gene involved in DNA repair and mutagenesis." Mol Gene Genet 232: 367-376.
Lieberman, H.B. and K.M. Hopkins (1994) "Schizosaccharomyces malidevorans and Sz. octosporus homologues of Sz. pombe rad9, a gene that mediates radioresistance and cell-cycle progression." Gene 150: 281-286.
Lieberman, H.B. (1995) "Extragenic suppressors of Schizosaccharomyces pombe rad9 mutations uncouple radioresistance and hydroxyurea sensitivity from cell cycle checkpoint control." Genetics 141: 107-117.
Okazaki, K., et al. (1990) "High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs by trans-complementation of Schizosaccharomyces pombe." Nucleic Acids Res 18: 6485-6489.
Savitsky, K., et al. (1995) "A single ataxia telangiectasia gene with a product similar to PI-3 kinase." Hum Mol Gen 268: 1749-1753.
Soares, M.B., et al. (1994) "Construction and characterization of a normalized cDNA library." Proc Natl Acad Sci U.S.A. 91: 9228-9232.
Weinert, T.A. and L.H. Hartwell (1990) "Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage." Mol Cell Biol 10: 6554-6564.
Davey Scott K.
Hopkins Kevin M.
Lieberman Howard B.
Campbell Eggerton A.
The Ontario Cancer Treatment and Research Foundation
The Trustees of Columbia University in the City of New York
White John P.
LandOfFree
Human radioresistance/cell cycle progression gene does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human radioresistance/cell cycle progression gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human radioresistance/cell cycle progression gene will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-816372