Human pyruvate dehydrogenese phosphatase

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

Reexamination Certificate

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C435S004000, C435S006120, C435S069100, C435S183000, C435S194000, C435S195000, C435S196000, C530S350000, C536S023200

Reexamination Certificate

active

10240774

ABSTRACT:
hPDP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hPDP polypeptides and polynucleotides in diagnostic assays.

REFERENCES:
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Lawson, Janet E., et al., Molecular cloning and expression of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase and sequence similarity with protein phosphatase 2C, Biochemistry, vol. 32, No. 35, 1993, pp. 8987-8993.
Database EMBL [Online] Accession No.: AI593115, Apr. 26, 1999, Marra, M., et al.: “vr31a07.y1 Barstead mouse myotubes MPLRB5 Mus musculus cDNA clone IMAGE: 1122228 5′ similar to SW:PDP—BOVIN P35816 [Pyruvate Dehydrogenase; mRNA sequence.”
Database EMBL [Online] Accession No.: HS10695, Jul. 2, 1995, Hillier, et al.: “ym07h07.r1 Soares infant brain 1NIBHomo sapienscDNA clone IMAGE: 47378 5′ similar to SP:PDP—BOVIN P35816 [Pyruvate Dehydrogenase;, mRNA sequence.”
Database EMBL [Online] Accession No. AI024308, Jun. 19, 1998, “ov67f02.x1 Soares—testisNHT Homo sapiens cDNA clone IMAGE:1642395 3′ similar to SW:PDP—BOVIN P35816 [Pyruvate Dehydrogenase:, mRNA sequence.”
Database EMBL [Online] Accession No: F05984, Feb. 14, 1995, Auffray, C., et al,: “H. sapienspartial cDNA sequence; clone c-0ta04.”
Database WPI, Section Ch, Week 200107, Derwent Pulications Ltd., London, GB; Class B04, AN 2001-050441 & CN 1 267 727 A (Southern Res Cent Nat Human Gene Group), Sep. 27, 2000.
Database EMBL [Online] Accession No.: AK022057, Sep. 29, 2000, Isogai, T., et al.: “Homo sapienscDNA FLJ11995 fis, clone HEMBB1001443, highly similar to Rattus norvegicus pyruvate dehydrogenase phosphatase isoenzyme 1 mRNA.”
Database EMBL [Online] Accession No.: AF155661, May 4, 2000, Peng, Y. et. al.: “Homo sapienspyruvate dehydrogenase (PDH) mRNA, complete cds.”
Database Biosis [Online], Biosciences Information Service, Philadelphia, PA, US; 1976, Stansbie D; “Regulation of the Human Pyruvate Dehydrogenase EC-1.2.4.1 Complex”, Database accession No. PREV197763038063 & Clinical Science and Molecular Medicine, vol. 51, No. 5, 1976, pp. 445-452, ISSN: 0301-0538.
Database BIOSIS [Online] Biosciences Information Service, Philadelphia, PA, US: 1981, Sheu K-F R et al.: “Pyruvate Dehydrogenase Complex Activity in Normal and Deficient Fibroblasts”, Database accession No. PREV198172081695 & Journal of Clinical Investigation, vol. 67, No. 5, 1981, pp. 1463-1471, ISSN: 0021-9738.
Database Biosis [Online] Biosciences Information Service, Philadelphia, PA, US; 1975, Robinson, B. H. et al.: “Pyruvate Dehydrogenase Phosphatase Deficiency A Cause of Congenital Chronic Lactic-Acidosis in Infancy”, Database accession No. PREV197661055864 & Pediatric Research, vol. 9, No. 12, 1975, pp. 935-939, ISSN: 0031-3998.

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