Human proton atpase subunit

Details Human proton atpase subunit Human proton atpase subunit

1997-02-27

2000-01-04

Achutamurthy, Pannathapu

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435195, 4352523, 4353201, 435325, 530350, 536 232, 536 235, 536 243, 536 2431, C12Q 168, C12N 914, C07K 100, C07H 2104

Patent

active

060108525

ABSTRACT:
The present invention provides a human proton ATPase subunit (HPAS) and polynucleotides which encode HPAS. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HPAS.

REFERENCES:
Mellman, I., et al., "Acidification of the Endocytic and Exocytic Pathways," Ann. Rev. Biochem., 55:663-700 (1986).
Mandel, M., et al., "cDNA sequence encoding the 16-kDa proteolipid of chromaffin granules implies gene duplication in the evolution of H+- ATPases,"0 Proc. Natl. Acad. Sci., 85:5521-5524 (1988) (GI 137477).
Apperson, M. et al., "A Yeast Protein, Homologous to the Proteolipid of the Chromaffin Granule Proton-Atpase, Is Important for Cell Growth," Biochemical and Biophysical Research Communications, 168 (2):574-579 (1990) (GI 172221).
Wilson, R., et al., "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. Elegans," Nature, 368:32-38 (1994) (GI 1132516).
Nishigori, H., et al. (GI 1694672), GenBank Sequence Database (Accession D89052) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Nishigori, H., et al. (GI 1694673), GenBank Sequence Database (Accession D89052) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Wilson, R., et al., (GI 1132516), GenBank Sequence Database (Accession Z68317) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Wilson, R., et al., (GI 1132515), GenBank Sequence Database (Accession Z68317) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Apperson, M., et al. (GI 172221), GenBank Sequence Database (Accession M35294), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Apperson, M., et al. (GI 172220), GenBank Sequence Database (Accession M35294), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Mandel, M. et al. (GI 137477) GenBank Sequence Database (Accession P23956) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Mandel, M., et al. (GI 162714) GenBank Sequence Database (Accession J03835; M61709) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Hillier et al. (Jan. 4, 1996), GenBank database, NID g1146668, accession N28432.
Hillier et al. (Oct. 6, 1995), GenBank database, NID g1012807, accession H59975.

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