Human protein tyrosine phosphatase OB protein

Details Human protein tyrosine phosphatase OB protein Human protein tyrosine phosphatase OB protein

1997-02-14

1999-02-02

Teng, Sally P.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 691, 530350, C12N 916, C12N 1555

Patent

active

058663975

ABSTRACT:
A novel human protein tyrosine phosphatase (PTP) has been identified and its cDNA has been isolated. This novel PTP, denoted PTP-OB, has a receptor-like three dimensional structure and is present in osteoblasts. PTP-OB is involved in osteoblast differentiation, and modulators of PTP-OB activity in turn modulate osteoblast differentiation, osteoclast differentiation and osteoclast activity.

REFERENCES:
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Wergedal et al. "Human Bone Cells Contain a Fluoride Sensitive Acid Phosphatase: Evidence that this Enzyme Functions at Neutral pH as a Phosphotyrosyl Protein Phosphatase"; Clin. Biochem. vol. 25, Feb. 1992; pp. 47-53.
Kaplan et al. "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain", Proc. Natl. Acad. Sci., vol. 87, pp. 7000-7004, 1990.
Chernoff et al. "Cloning of a cDNA for a major human protein-tyrosine-phosphatase", Proc. Natl. Acad. Sci, vol. 87, pp. 2735-2739, Apr. 1990.
Krueger et al. "A human transmembrane protein tyrosine phosphatase, PTP, is expressed in bring and has an N-terminal receptor domain homologous to carbonic anhydrases", Proc. Natl. Acad. Sci., vol. 89, pp. 7417-7421, Aug. 1992.
Hashimoto et al. "Insulin receptor and epidermal growth factor receptor dephosphorylation by three major rat liver protein-tyrosine phosphatases expressed in a recombinant bacterial system", J. Biochem. vol. 284, (1992) pp. 569-572.
Lau et al. "Purification and Characterization of an Acid Phosphatase that Displays Phosphotyrosyl protein Phosphatase Activity from Bovine Cortical Bone Matrix", J. of Biol. Chem. vol. 262, No. 3, pp. 1389-1397, 1987.
Lau et al. "Phosphotyrosyl protein phosphatases", Biochem. (1989) vol. 257, pp. 23-26.
Mizuno et al. "Developmental regulation of gene expression for the MPTp isoforms in the central nervous system and the immune system", FEBS Letters 355 (1994) 223-228.

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