Human protein kinases hYAK3

Details Human protein kinases hYAK3 Human protein kinases hYAK3

1999-07-22

2000-12-26

Nashed, Nashaat T.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

536 232, 536 235, C12N 912

Patent

active

061657662

ABSTRACT:
hYAK3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK3 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers including testicular cancer; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome., among others, and diagnostic assays for such conditions.

REFERENCES:
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Accession No. Z70308, Wilson et al., "Direct Submission" Mar.1996.
Accession No. H62028, Hillier et al., Homo sapiens cDNA clone 209224 Similar to yeast protein kinase YAKI, Oct. 1995, EMBL Sequence Database.
Accession No. AA002193, "Homo sapiens cDNA clone 428049 similar to serine/threonine kinase c16c9.7", Jul. 1996, EMBL Sequence Database.
Tugendreich S. et al., "Linking Yeast Genetics t Mammalia Genomes: Identification and Mapping of the Human Homolog of CDC27 Via the Expressed Sequence Tag Database" Proc. Natl. Acad. of Science, vol. 90 (21), Nov. 1993, pp. 10031-10035.
Garrett S. et al., "The Saccharomyces cerevisiae yaki gene encodes of protein that is induced by arrest early in the cell cycle", Molecular and Cellular Biology, vol. 11(8), pp. 4045-4052, Aug. 1991.
Accession No. Y12735, Becker et al., "Homo sapiens mRNA for protein kinase Dyrk3", Jan. 1998, EMBL Sequence Database.

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