Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-06-27
1999-07-13
Scheiner, Laurie
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
530350, 530326, 530325, 530324, 435 5, 435 691, 4241851, 4242081, C07H 2104, C07K 100, C12Q 170, A61K 3900
Patent
active
059228563
ABSTRACT:
The present invention provides a human cellular polypeptide, termed hRIP, that is necessary for HIV replication. The polypeptide has a molecular mass of about 59 kDa, having the sequence set forth in FIG. 2a (SEQ ID NO:1). hRIP is the cellular cofactor required to mediate the Rev response. hRIP binds HIV Rev protein and is essential for Rev activity. The invention also includes nucleic acid sequences encoding hRIP, as well as DNA vectors and transformed cells suitable for recombinant expression of this polypeptide.
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Fritz Christian C.
Green Michael R.
Park Hankyel T.
Scheiner Laurie
University of Massachusetts
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