Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2004-09-22
2009-02-10
Prouty, Rebecca E (Department: 1656)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S015000, C435S007920, C435S320100, C435S325000, C536S023200
Reexamination Certificate
active
07488592
ABSTRACT:
The present invention provides the identification of human Ras palmitoyl acyl transfersase complexes, and nucleic acids coding therefore. In addition, methods of screening for modulators of human Ras palmitoyl acyl transfersase, including high throughput yeast screens, are also provided.
REFERENCES:
Amit K. Das‡, Biplab Dasgupta, Raja Bhattacharya§, and Joyoti Basu. Purification and biochemical characterization of a protein-palmitoyl acyltransferase from human erythrocytes. Journal of Biological Chemistry (1997), 272(17), 11021-11025, 1997:302533.).
Lobo et al. (Journal of Biological Chemistry vol. 277, No. 43, Issue of Oct. 25, pp. 41268-41273, 2002).
Varner et al (Analytical Biochemistry 308 (2002) 160-167. A fluorescence-based high performance liquid chromatographic method for the characterization of palmitoyl acyl transferase activity.
Li Liu et al Purification of a Protein Palmitoyltransferase that Acts on H-Ras Protein and on a C-terminal N-Ras Peptide. J. of Biological Chemistry vol. 271, No. 38, Issue of Sep. 20, 1996 pp. 23269-23276.
Liu et al. Purification of a protein palmitoyltransferase that acts on H-Ras protein and on C-terminal N-Ras peptide. JBC, Jan. 1999, 274, 3252 published as additional corrections.
Dietrich and Ungermann, “On the mechanism of protein palmitoylation,”EMBO reports, 5(11):1053-1057, 2004.
Fukata et al., “Identification of PSD-95 palmitoylating enzymes,”Neuron, 44:987-996, 2004.
Roth et al., “The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase,”J Cell Biol, 159(1):23-28, 2002.
Bartels et al., “Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 insaccharomyces cerevisiae,”Mol. Cell. Biol., 19:6775-6787, 1999.
Berthiaume and Resh, “Biochemical characterization of a palmitoyl acyltransferase activity that palmitoylates myristoylated proteins,”J. Biol. Chem., 270:22399-22405, 1995.
Bohm et al., “Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins,”Nucleic Acids Res., 25:2464-2469, 1997.
Dunphy et al., “Differential effects of acyl-CoA binding protein on enzymatic and non-enzymatic thioacylation of protein and peptide substrates,”Biochim. Biophys. Acta, 1485:185-198, 2001.
Dunphy et al., “G-protein palmitoyltransferase activity is enriched in plasma membranes,”J. Biol. Chem., 271:7154-7159, 1996.
Dunphy et al., “Enrichment of G-protein palmitoyltransferase activity in low density membranes,”J. Biol. Chem., 276:43300-43304, 2001.
Jung et al., “Mutations in theSHR5gene ofsaccharomyces cerevisiaesuppress ras function and block membrane attachment and palmitoylation of ras proteins,”Mol. Cell. Biol., 15:1333-1342, 1995.
Linder & Deschenes, “New insights into the mechanisms of protein palmitoylation,”Biochem42(15):4311-4320, 2003.
Linder and Deschenes, “Model organisms lead the way to protein palmitoyltransferases,”J Cell Sci, 117:521-526, 2004.
Linder, In:The Enzymes: Protein Lipidatio, Tamanoi and Sigman (Eds.),vol. XXI:215-240, Academic Press, San Diego, 2001.
Liu et al., “Purification of a protein palmitoyltransferase that acts on H-ras protein and on a C-terminal N-ras peptide,”J. Biol. Chem., 271:23269-23276, 1996.
Lobo et al., “Identification of a ras palmitoyltransferase insaccaromyces cerevisiae,”J. Biol. Chem., 277:41268-41273, 2002.
Mitchell et al., “A polybasic domain allows nonprenylated ras proteins to function insaccharomyces cerevisiae,”J. Biol. Chem., 269:21540-21546, 1994.
Putilina et al., “The DHHC domain: a new highly conserved cysteine-rich motif,”Mol. Cell. Biochem, 195:219-226, 1999.
Schmidt and Burns, “Hydrophobic modifications of membrane proteins by palmitoylation in vitro,”Biochem. Soc. Trans., 17:625-626, 1989.
Deschenes Robert J.
Linder Maurine E.
Lobo Sandra
Swarthout John
Gebreyesus Kagnew H
Prouty Rebecca E
The University of Iowa Research Foundation
Washington University
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