Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-09-03
1998-08-11
Saunders, David
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 691, 4351723, 4353201, 530350, 5303882, 5303891, 5303913, C07H 2104, C07K 1628, C12N 1512
Patent
active
057928517
ABSTRACT:
The present invention provides a purified and isolated nucleic acid encoding human prostaglandin transporter (hPGT). The present invention also provides a vector comprising a nucleic acid encoding human prostaglandin transporter (hPGT), a cell stably transformed with this vector, as well as a method for producing a recombinant, human prostaglandin transporter (hPGT). The present invention also provides a purified and isolated human prostaglandin transporter (hPGT), and an antibody immunoreactive with this protein. The present invention further provides a method for evaluating the uptake of a selected prostaglandin by cells expressing nucleic acid encoding human prostaglandin transporter (hPGT). Finally, the present invention provides a vector and an embryonic stem cell each of which comprises nucleic acid encoding a mutant human prostaglandin transporter (hPGT), a non-human transgenic animal whose germ and somatic cells contain nucleic acid encoding a mutant human prostaglandin transporter (hPGT) introduced into said animal, or an ancestor thereof, at an embryonic stage, as well as a method for producing the non-human, transgenic animal.
REFERENCES:
Run Lu, Cloning, Tissue Expression and Functional Characterization of a Human Prostaglandin Transporter, J. Am. Soc. Nephrol. 6: 757, 1995 (Abstract) Presented at the American Society of Nephrology 28th Annual Meeting, San Diego, CA, Nov. 8, 1995.
Kanai, et al., Identification and Characterization of a Prostaglandin Transporter, Science, 268: 866-69 (May 12, 1995).
Kanai, et al. OATP-2, A Novel Prostaglandin Transporter: Substrate and Inhibitor Specificities and Affiritis, J. Am Soc Nephrol. 5: 311 (1994) (Abstract).
Lu, R et al. J. Clin. Invest. 98(5): 1142-1149, Sep. 1996.
Johnstone, A et al, Immunology in Practice, Johnstoine and Thorpe, eds. Blackwell Scientific Publications, Oxford, UK., 1987.
Lu Run
Schuster Victor L.
Albert Einstin College of Medicine of Yeshiva University, a Divi
Saunders David
Vander Vegt F. Pierre
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