Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-01-22
2008-01-22
Ulm, John (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210, C435S069100, C530S350000
Reexamination Certificate
active
10620289
ABSTRACT:
The invention provides an isolated polypeptide containing the amino acid sequence of SEQ ID NO: 17, 18, 19, 20, 21, 22, 23, 24, or 25. The invention also provides an isolated polypeptide containing an amino acid sequence having at least 50% amino acid identity with SEQ ID NO: 14 and an amino acid sequence of SEQ ID NO: 17, 18, 19, 20, 21, 22, 23, 24, or 25, or a conservative variant thereof. The invention further provides an isolated polypeptide containing the amino acid sequence of SEQ ID NO: 2, 4, 6, 8, 10, or 12. The invention also provides a method for identifying a compound that modulates a FP receptor variant by contacting an isolated FP receptor variant or a FP receptor variant over-expressed in a genetically engineered cell with a compound and determining the level of an indicator which correlates with modulation of a FP receptor variant, where an alteration in the level of the indicator as compared to a control level indicates that the compound is a compound that modulates the FP receptor variant.
REFERENCES:
patent: 5869281 (1999-02-01), Abramovitz et al.
patent: 6329426 (2001-12-01), Ueno
patent: 6416972 (2002-07-01), Lake et al.
patent: 6492417 (2002-12-01), Sharif et al.
patent: 6511999 (2003-01-01), Burk et al.
patent: 2004/0082013 (2004-04-01), Regan
patent: WO 00/29614 (2000-05-01), None
patent: WO 03/070902 (2003-08-01), None
Abramovitz et al., “Cloning and expression of a cDNA for the human prostanoid FP receptor,”J. Biol. Chem. 269:2632-2636 (1994).
Anderson et al., “Prostaglandin F2αreceptor in the corpus luteum: Recent information on the gene, messenger ribonucleic acid, and protein,”Biology of Reproduction64:1041-1047 (2001).
Anderson et al., “Prostaglandin moieties that determine receptor binding specificity in the bovine corpus luteum,”J. Reprod. Fertil. 116:133-141 (1999).
Betz et al., “Genomic structure, 5′ flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene,”Biochem. Biophys. Res. Commun.254:413-416 (1999).
Bhattacharya et al., “Nuclear prostaglandin receptors,”Gene Ther. Mol. Biol. 4:323-338 (1999).
Boiti et al., “Nitric oxide synthase activity and progesterone release by isolated corpora lutea of rabbits in the early and mid-luteal phases of pseudopregnancy are modulated differently by prostaglandin E-2 and prostaglandin F-2alpha via adenylate cyclase and phospholipase C,”J. Endocrinol. 164:179-186 (2000).
Carrasco et al., “Activation of the prostaglandin FP receptor in human granulosa cells,”J. Reprod. Fertil. 111:309-317 (1997).
Chen et al., “Prostaglandin F2alpha stimulates the Raf/MEK1/mitogen-activated protein kinase signaling cascade in bovine luteal cells,”Endocrinology139:3876-3885 (1998).
Davis et al., “Prostaglandin F2 alpha stimulates phosphatidylinositol 4,5-bisphosphate hydrolysis and mobilizes intracellular Ca2+ in bovine luteal cells,”Proc. Natl. Acad. Sci. USA84:3728-3732 (1987).
Duncan et al., “Chromosomal localization of the human prostanoid receptor gene family,”Genomics25:740-742 (1995).
Ezashi et al., “Genomic organization and characterization of the gene encoding bovine prostaglandin F2alpha receptor,”Gene190:271-278 (1997).
Fu et al., “Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3,”J. Biol. Chem. 276:45888-45894 (2001).
Fujino et al., “Delayed reversal of shape change in cells expressing FP(B) prostanoid receptors. Possible role of receptor resensitization,”J. Biol. Chem. 275:29907-29914 (2000).
Graves et al., “Cloning of a receptor for prostaglandin F2 alpha from the ovine corpus luteum,”Endocrinology136:3430-3436 (1995).
Griffin et al., “FP prostaglandin receptors mediating inositol phosphates generation and calcium mobilization in Swiss 3T3 cells: A pharmacological study,”J. Pharmacol. Exp. Ther. 281:845-854 (1997).
Gusovsky, “Prostaglandin receptors in NIH 3T3 cells: Coupling of one receptor to adenylate cyclase and of a second receptor to phospholipase C,”Mol. Pharmacol. 40:633-638 (1991).
Hasumoto et al., “Characterization of the mouse prostaglandin F receptor gene: A transgenic mouse study of a regulatory region that controls its expression in the stomach and kidney but not in the ovary,”Genes Cells2:571-580 (1997).
Ishikawa et al., “Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors,”Genomics32:285-288 (1996).
Juengel et al., “Regulation of steady-state concentrations of messenger ribonucleic acid encoding prostaglandin F2 alpha receptor in ovine corpus luteum,”Biol. Reprod. 54:1096-1102 (1996).
Kiriyama et al., “Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells,”Br. J. Pharmacol. 122:217-224 (1997).
Kitanaka et al., “Cloning and expression of a cDNA for rat prostaglandin F2 alpha receptor,”Prostaglandins48:31-41 (1994).
Lake et al., “Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor,”FEBS Lett. 355:317-325 (1994).
Liang et al., “Comparison of PGF2α, Bimatoprost (prostamide) and butaprost (EP2 agonist) of Cyr61 and CTGF gene expression,”J. Biol. Chem. 278:27267-27277 (2003).
Liu et al., “PLD activation in Chinese hamster ovary (CHO) cells transfected with PGF2 alpha receptor cDNA,”Prostaglandins51:233-248 (1996).
Narumiya and FitzGerald, “Genetic and pharmacological analysis of prostanoid receptor function,”J. Clin. Invest. 108:25-30 (2001).
Niswender et al., “Mechanisms controlling the function and life span of the corpus luteum,”Physiol. Rev. 80:1-29 (2000).
Ogawa et al., “Structural organization and chromosomal assignment of the human prostacyclin receptor gene,”Genomics27:142-148 (1995).
Pierce and Regan, “Prostanoid receptor heterogeneity through alternative mRNA splicing,”Life Sciences62:1479-1483 (1998).
Pierce et al., “Activation of FP prostanoid receptor isoforms leads to Rho-mediated changes in cell morphology and in the cell cytoskeleton,”J. Biol. Chem. 274:35944-35949 (1999).
Pierce et al., “Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor,”J. Biol. Chem. 272:883-887 (1997).
Sakamoto et al., “Expression of mRNA encoding the prostaglandin F2 alpha receptor in bovine corpora lutea throughout the oestrous cycle and pregnancy,”J. Reprod. Fertil. 103:99-105 (1995).
Sakamoto et al., “Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor,”J. Biol. Chem. 269:3881-3886 (1994).
Sakamoto et al., “Prostaglandin F2 alpha receptor,”J. Lipid Mediat. Cell Signal12:405-411 (1995).
Stjernschantz et al., “Microvascular effects of selective prostaglandin analogues in the eye with special reference to latanoprost and glaucoma treatment,”Prog. Retin. Eye Res. 19:459-496 (2000).
Sugimoto et al., “Cloning and expression of a cDNA for mouse prostaglandin F receptor,”J. Biol. Chem. 269:1356-1360 (1994).
Susanna et al., “Current status of prostaglandin theory: Latanoprost and unoprostone,”Surv. Ophthalmol.47:S97-104 (2002).
Taketo et al., “Mapping of the genes encoding mouse thromboxane A2 receptor and prostaglandin E-receptor subtypes EP2 and EP3,”Genomics19:585-588 (1994).
Tsai et al., “Distinct mechanisms regulate induction of messenger ribonucleic acid for prostaglandin (PG) G/H synthase-2, PGE (EP3) receptor, and PGF2 alpha receptor in bovine preovulatory follicles,”Endocrinology137:3348-3355 (1996).
Tsai et al., “Regulation of pros
Liang Yanbin
Woodward David F.
Allergan Inc.
German Joel B.
Stathakis Dean G.
Ulm John
Voet Martin A.
LandOfFree
Human prostaglandin FP receptor variants and methods of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human prostaglandin FP receptor variants and methods of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human prostaglandin FP receptor variants and methods of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3917770