Human proinsulin pharmaceutical formulations

Details Human proinsulin pharmaceutical formulations Human proinsulin pharmaceutical formulations

1984-12-17

1987-03-31

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 3, A61K 3700

Patent

active

046543244

ABSTRACT:
A pharmaceutical composition which comprises human proinsulin in association with a pharmaceutically acceptable carrier is useful in controlling a diabetic condition and in promoting attainment of natural hormonal homeostasis, thereby preventing or substantially diminishing or retarding diabetic complications.

REFERENCES:
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Horwitz et al., J. Clin. Invest., 55, 1278-1283 (1975).
Kitabchi, Metabolism, 26, 547-587 (1977).
Yanaihara et al., Diabetes, 27 (Suppl. 1), 149-160 (1978).
Yanaihara et al., Characterization of Synthetic Human Proinsulin and C-Peptide, Proinsulin, Insulin, C-Peptide, 41-49 (Excerpta Medica, 1979).
Rees et al., Diabetes, 18, 341 (1969).
Galloway et al., Diabetes, 18, 341 (1969).
Galloway et al., J. Lab. Clin. Med., 78, 991-992 (1971).
Kitabchi, South. Med. J., 65, 833-838 (1972).
Low et al., Nature, 248, 339-340 (1974).
Starr et al., J. Clin. Endocrinol. Metab., 38, 305-308 (1974).
Tompkins et al., Diabetologia, 20, 94-101 (1981).
Fineberg et al., Diabetes, 22, 676-686 (1973).

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