Human preprotachykinin B

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 2, 530350, 530324, 435 691, A61K 3800

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active

060081945

ABSTRACT:
The invention provides a human preprotachykinin B (PPT-B) and polynucleotides which identify and encode PPT-B. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PPT-B.

REFERENCES:
patent: 5268359 (1993-12-01), Harmar et al.
Stryer L. (1981) Biochemistry, WH Freeman and Co., New York, San Francisco.
Kontani et al. (1988) GenBank Database, Accession No. A25905.
Kotani et al. (1986) "Structure and gene organization of bovine neuromedin K precursor", Proc. Natl. Acad. Sci. USA 83:7074-78.
Stewart, J.M. et al., "Neuropeptide Processing In Pathophysiology", Agents Actions Suppl., 42:211-226 (1993).
Helke, C.J. et al., "Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms", FASEB J., 4:1606-1615 (1990).
Nakanishi, S., "Substance P Precursor and Kininogen: Their Structures, Gene Organizations, and Regulation", Physiol. Rev., 67:1117-1142 (1987).
Toresson, G. et al., "N-terminally extended tachykinins in human cerebrospinal fluid", Regul. Pept., 46:357-359 (1993).
Otsuka, M. et al., "Neurotransmitter Functions of Mammalian Tachykinins", Physiol. Rev., 73:229-308 (1993).
Kotani, H. et al., "Structure and gene organization of bovine neuromedin K precursor", Proc. Natl. Acad. Sci. USA, 83:7074-7078 (1986) (GI 163580; GI 163590).
Lang, S. et al., "Neurochemical characterization of preprotachykinin B(50-79) immunoreactivity in the rat", Regul. Pept., 57:183-192 (1995).
Bonner, T.I. et al., "A cDNA encoding the precursor of the rat neuropeptide, neurokinin B", Mol. Brain Res., 2:243-429 (1987) (GI 205724; GI 205725).
Wenk, G.L. et al., "Neuroprotection of acetylcholinergic basal forebrain neurons by memantine and neurokinin B", Behav. Brain Res., 83:129-133 (1997).
Schwarzer, C. et al., "Neuropeptides-immunoreactivity and their mRNA expression in kindling: functional implications for limbic epileptogenesis", Brain Res. Rev., 22:27-50 (1996).
McGregor, G.P. et al., "Neurokinin-immunoreactivity in human neuroblastomas--Evidence for selective expression of the preprotachykinin (PPT) II gene", FEBS Lett., 277:83-87 (1990).
Wagner, U. et al., "Galanin And Somatostatin Inhibition Of Neurokinin A And B Induced Airway Mucus Secretion In The Rat", Life Sci., 57:283-289 (1995).
Killingsworth, C.R. et al., "Tachykinin receptors mediating contraction of guinea pig lung strips", Regul. Pept., 57:149-161 (1995).
Stratowa, C. et al., "Functional Characterization Of The Human Neurokinin Receptors Nk1, NK2, And NK3 Based On A Cellular Assay System", J. Recept. Signal Transduct. Res., 15:617-630 (1995).
Kako, K. et al., "Cloning And Sequence Analysis Of Mouse cDNAs Encoding Preprotachykinin A and B", Biomedical Rearch, 14:253-359 (1993).
Kako, K. et al., GenBank Database, Accession No. I65342, Aug. 2, 1996.
Hillier, L. et al., "zh89a10.rl Soares fetal liver spleen 1NFLS S1 Homo sapiens cDNA clone c428442 5' similar to SW: TKNK Bovin Nuerokinin B Precursor", EMBL Database, Jul. 25, 1996, (Accession No. AA004764).

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