Human preproinsulin-like growth factor I

Details Human preproinsulin-like growth factor I Human preproinsulin-like growth factor I

1990-03-15

1991-12-03

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530397, 530399, 530303, 530305, 514 3, C07K 710, C07K 740, A61K 3724

Patent

active

050700758

ABSTRACT:
The invention provides DNA sequences encoding a human preproinsulin-like growth factor I protein and novel extension peptides. A novel preproinsulin-like growth factor I protein and novel extension peptides are also provided. The present invention further provides a human IGF-I gene which has been sequenced and which encodes at least two preproinsulin-like growth factor-I proteins. Various genes and DNA sequences useful in producing essentially pure mature IGF-I, preproinsulin-like growth factor I proteins and IGF-I gene related proteins are also provided.

REFERENCES:
patent: 4963665 (1990-10-01), Rothwein
Rinderknect et al., The Journal of Biological Chemistry, vol. 253, No. 8, pp. 2769-2776 (1978).
Rinderknect et al., FEBS Letters, vol. 89, No. 2, pp. 283-285 (1978).
Talmadge et al., Proc. Natl. Acad. Sci. U.S.A., vol. 77, No. 7, pp. 3988-3992 (1980).
Vassilopoulou-Sellin et al., Endocrinology, vol. 110, No. 2, pp. 582-589 (1982).
Li et al., Proc. Natl. Acad. Sci. U.S.A., vol. 80, pp. 2216-2220 (1983).
Jansen et al., Nature, vol. 306, pp. 609-611 (1983).
Zumstein et al., Proc. Natl. Acad. Sci. U.S.A., vol. 82, pp. 3169-3182 (1985).
Bell et al., Proc. Natl. Sci. U.S.A., vol. 82, pp. 6450-6454 (1985).

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