Human prealbumin and related methods and products

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 68, 4351723, 435320, 435803, 43525233, 436808, 436811, 536 27, 935 11, 935 29, 935 78, 935 80, C12Q 168, C07H 1512, C12N 1500

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048163880

ABSTRACT:
Recombinant human prealbumin and a method for producing such human prealbumin through recombinant DNA techniques including preparation and isolation of a cDNA sequence coding for human prealbumin, construction of a cloning vector and an expression vector containing said cDNA sequence, and expression of human prealbumin in a prokaryotic cell transformed by said expression vector are disclosed. The invention further relates to the use of human prealbumin cDNA in the diagnosis by hybridization methodologies of medical conditions with which variant forms of prealbumin are associated. Also disclosed is a method for diagnosing some Type I familial amyloid polyneuropathies by a restriction endonuclease assay with an enzyme which recognizes the nucleotide base sequence 5'-ATGCAT-3'.

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Wallace, M. R. et al., "Localization of the Human Prealbumin Gene", Biochem. Biophys. Res. Comm. 129 (3), 753-758 (6/28/85).
Tzuzuke, T., et al., "Structure of the Human Prealbumin Gene", J. Biol. Chem. 260 (22), 12224-12227 (10/5/85).
Benson, M. D., et al., J. Clin. Invest. (1985) 75:71-75.
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Mita, S. et al., Biochemical and Biophysical Research Coomunications Academic Press, Inc., vol. 124, No. 2, 1984, pp. 558-564.

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