Human pluripotent hematopoietic colony stimulating factor and ce

Details Human pluripotent hematopoietic colony stimulating factor and ce Human pluripotent hematopoietic colony stimulating factor and ce

1997-12-22

2000-09-05

Kemmerer, Elizabeth

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

C12N 508

Patent

active

061141666

ABSTRACT:
Highly purified Pluripotent hematopoietic colony-stimulating factor (pluripotent CSF), a glycoprotein (MW 19,600) constitutively produced by human tumor cells has been highly purified from low serum-containing conditioned medium to apparant homogeneity. Pluripotent CSF supports the growth of human mixed colonies (CFU-GEMM), granulocyte-macrophage colonies (CFU-GM), early erythroid colonies (BFU-E) and induces differentiation of human leukemic cells. The specific activity of the purified pluripotent CSF in the CFU-GM assay is 1.5.times.10.sup.8 U/mg protein.

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