Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1994-05-09
2000-08-29
Priebe, Scott D.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
4352542, 4353201, 435358, 435361, 435455, 435471, 536 231, 536 235, 536 2431, C12N 119, C12N 516, C12N 1581, C12N 1585
Patent
active
061107379
ABSTRACT:
A DNA sequence encoding human platelet-derived growth factor receptor (hPDGF-R) has now been isolated and sequenced. An expression construct comprising the sequence encodes a receptor that can be secreted or incorporated into the membrane of a mammalian cell. The incorporated receptor is functionally equivalent to the wild-type receptor, conferring a PDGF-sensitive mitogenic response on cells lacking the receptor. The construct can be used for enhancing PDGF response of cells, determining the regions involved in transducing the signal in response to PDGF binding, providing mutated analogs and evaluating drugs for their physiologic activity.
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Escobedo Jaime A.
Williams Lewis T.
Priebe Scott D.
The Regents of the University of California
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