Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1998-03-20
2000-08-15
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435 691, 435196, 530350, C12N 916
Patent
active
061035106
ABSTRACT:
The invention provides a novel phospholipase A.sub.2 enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
REFERENCES:
patent: 5045462 (1991-09-01), Menez et al.
patent: 5328842 (1994-07-01), Chiou et al.
Nalefski et al. (1994) "Delineation of Two Functionally Distinct Domains of Cytosolic Phospholipase A2, a Regulatory Ca2+-dependent Lipid-binding Domain and a Ca2+-independent Catalytic Domain" J. Biol. Chem. 269/27:18239-49.
Nalefski et al. (1996) "Cytosolic Phospholipase A2--Chicken" GB/EMBL/DDBJ Database, Accession No. I50699.
Leslie et al. (1988) "Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7" Biochem. Biophys. Acta 963:476-92.
Molecular weight calculation of polypeptide encoded by SEQ ID No:2 using Intelligenetics PEP-Polypeptide Analysis System Version 5.4. Jan. 13, 1999 .
Kramer Ruth Maria
Pickard Richard Todd
Sharp John David
Strifler Beth Ann
Eli Lilly and Company
Gaylo Paul J.
Longton Enrique D.
Wax Robert A.
Wilson Alexander
LandOfFree
Human phospholipase A.sub.2 and related nucleic acid compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human phospholipase A.sub.2 and related nucleic acid compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human phospholipase A.sub.2 and related nucleic acid compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2005295