Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1995-12-22
1998-12-22
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 691, 4353201, 435196, 435325, 536 232, 536 235, C12Q 144
Patent
active
058517847
ABSTRACT:
Recombinant human phosphodiesterase type IVC is described, and DNA coding for it. Particular conformers of the enzyme are identified, including a R- and S-rolipram stereoselective conformer which is obtainable by expression of human phosphodiesterase type IVC DNA in mammalian or insect cells. The recombinant enzyme may be used in a screen to select a compound capable of modulating the action of the enzyme, or as an immunogen to generate an antibody.
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Lumb Simon Mark
Owens Raymond John
Perry Martin John
Celltech Therapeutics Limited
Longton Enrique D.
Prouty Rebecca E.
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