Human phosphatidylinositol transfer protein gamma

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 2, 530350, 530300, 435 691, A61K 3800

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060340630

ABSTRACT:
The invention provides a new human phosphatidylinositol transfer protein gamma (PITP.gamma.) and polynucleotides which identify and encode PITP.gamma.. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PITP.gamma..

REFERENCES:
Vihtelic et al. (1991) "Isolation and Characterization of the Drosophila retinal degeneration B (rdgB) Gene" Genetics 127:761-768.
Vihtelic et al. (1994) "Probable Calcium Transporter rdgB-Fruit Fly (Drosophila Melanogaster)" GenBank Database, Accession No. A61221.
Wirtz, K.W.A., "Phospholipid Transfer Proteins", Annu. Rev. Biochem., 60: 73-99 (1991).
Ohashi, M. et al., "A role for phosphatidylinositol transfer protein in secretory vesicle formation", Nature, 377: 544-547 (1995).
Thomas, G.M.H. et al., "An Essential Role for Phosphatidylinositol Transfer Protein in Phospholipase C-Mediated Inositol Lipid Signaling", Cell, 74: 919-928 (1993).
Hay, J.C. et al., "Phosphatidylinositol transfer protein required for ATP-dependent priming of Ca.sup.2+ -activated secretion", Nature, 366: 572-575 (1993).
Bankaitis, V.A. et al., "The Saccharomyces cerevisiae SEC14 Gene Encodes a Cytosolic Factor That Is Required for Transport of Secretory Proteins from the Yeast Golgi Complex", J. Cell Biol., 108: 1271-1281 (1989).
Bankaitis, v.A. et al., "An essential role for a phospholipid transfer protein in yeast Golgi function", Nature, 347: 561-562 (1990).
Dickeson, S.K. et al., "Sequence of a human cDNA encoding phosphatidylinositol transfer protein and occurrence of a related sequence in widely divergent eukaryotes", Gene, 142: 301-305 (1994) (GI 189939).
Tanaka, S. et al., "Cloning and expression of human cDNA encoding phosphatidylinositol transfer protein .beta.", Biochim. Biophys. Acta, 1259: 199-202 (1995) (GI 1346772).
Kauffmann-Zeh, A. et al., "Requirement for Phosphatidylinositol Transfer Protein in Epidermal Growth Factor Signaling", Science, 268: 1188-1190 (1995).
Cunningham, E. et al., "Phosphatidylinositol transfer protein dictates the rate of inositol trisphosphate production by promoting the syntheis of PIP.sub.2 ", Curr. Biol., 5: 775-783 (1995).
Capitani, S. et al., "Inositol Lipid Phosphorylation In The Cell Nucleus", Adv. Enzyme Reg., 31: 399-416 (1991).
Alb, J.G. et al., "Mutant rat phosphatidylinositol/ phosphatidylcholine transfer proteins specifically defective in phosphatidylinositol transfer: Implications for the regulation of phospholipid transfer activity", Proc. Natl. Acad. Sci. USA, 92: 8826-8830 (1995).
McCance, K.L. et al., Pathophysiology, (2nd Ed.), Mosby-Year Book, Inc., St. Louis, MO, p. 20, (1994).
Berridge, M.J. et al., "Calcium signalling and cell proliferation", BioEssays, 17: 491-500 (1995).
van Paridon, P.A. et al., "Properties of the Binding Sites for the sn-1 and sn-2 Acyl Chains on the Phosphatidylinositol Transfer from Bovine Brain", Biochemistry, 27: 6208-6214 (1988).
Hillier, L. et al.: `Homo sapiens cDNA clone 364436 5 ` similar to SW: RDGB.sub.-- DROME P43125 retinal degeneration B protein, EMEST Database entry Hsa2Hsa22885; Aug. 10, 1996, Accession No. AA022885, XP002081832.
Dickenson, S.K. et al.: `Phosphatidylinositol transfer protein alpha isoform`, SWISSPROT Database entry: Ppil.sub.-- Human; Dec. 1, 1991, Accession No. Q00169, XP002081834.
De Vries, et al.: `Phosphatidylinositol-transferprotein isoform, 36K-bovine.`, PIR Database entry S58431, Feb. 12, 1998, Accession number S58431, XP002081835.
Hara, S. et al., "The First 5 Amino Acids of the Carboxyl Terminus of Phoaphatidylinositol Transfer Protein (PITP) .alpha. Play a Critical Role in Inositol Lipid Signaling", Journal of Biological Chemistry, 272: 14908-14913 (1997).
Reeck, G.R., et al., "Homology in Proteins and Nucleic Acids: A Terminology Muddle and a Way out of It", Cell, 50:667 (1987).
Hillier, L. et al., EST Database, Accession No. AA035468 (1997).
Adams, M.D. et al., EST Database, Accession No. AA370865 (1997).

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