Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1998-06-19
1999-06-15
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
435196, 514 12, 530300, A61K 3848, C12N 916
Patent
active
059119845
ABSTRACT:
The invention provides a human peroxisomal thioesterase (PxTE) and polynucleotides which identify and encode PxTE. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PxTE.
REFERENCES:
Smith, S. "Long-chain fatty acyl-S-4'-phosphopantetheine-fatty acid synthase thioester hydrolase from rat." Method Enzymol. (1981) 71:181-188.
Smith, S. "Medium-chain fatty acyl-s-4'-phosphopantetheine-fatty acid synthase thioester hydrolase from lactating mammary gland of rat." Methods Enzymol. (1981) 71:188-200.
Naggert, J. et al., "Cloning, Sequencing, and Characterization of Escherichia coli Thioesterase II" J. Biol. Chem. (1991) 266(17):11044-11050. (GI 147932).
Baumgart, E. et al., "Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome." Proc.Natl.Acad.Sci.USA (1996) 93:13748-13753
Watkins, P. et al., "Distinction Between Peroxisomal Bifunctional Enzyme and Acyl-CoA Oxidase Deficiencies." Ann.Neurol. (1995) 38:472-477.
Fang, H. et al., "The Homologue of Mammalian SPC12 is Important for Efficient Signal Peptides Activity in Saccharomyces cerevisiae." J.Biol.Chem. (1996) 271(28):16460-16465. (GI 854594).
Corley Neil C.
Hillman Jennifer L.
Shah Purvi
Bugaisky Gabriele E.
Incyte Pharmaceuticals Inc.
Price, Esq. Leanne C.
Wax Robert A.
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