Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1995-03-21
1997-11-04
Elliott, George G.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435 6, 435 9131, 4351721, 4351723, 4352401, 4353201, 514 44, 536 232, 536 245, 536 253, C12P 1934, C12N 1500, C12N 500, C07H 2102
Patent
active
056839022
ABSTRACT:
Synthetic catalytic RNAs, i.e. ribozyme, including a hairpin portion, binding sites for binding to a human papilloma virus after viral base 419 and 434, respectively, and cleavage sites for cleaving the virus at the binding sites have been constructed.
REFERENCES:
Altschuler et al., 1992, Gene 122:85-90, "A method for generating transcripts with defined 5'and 3'termini by autolytic processing".
Anderson et al., 1994, Nucleic Acids Research 22 (6):1096-1100, "Mutagenesis of the haripin ribozyme".
Cepko et al., 1984, Cell, 37:1053-1062, "Construction and Applications of a Highly Transmissible Murine Retrovirus Shuttle Vector" (Jul.).
Chatterjee and Wong, 1993, Methods: Companion to Methods in Enzymology 5(1):51-59, "Adeno-Associated Viral Vectors for Delivery of Antisense RNA".
Cheong et al., 1990, Nature 346:680-682, "Solution structure of an unusually stable RNA hairpin, 5'GGAC(UUCG)GUCC".
Das et al., 1988, Embo Journal 7(2):503-512, "Upstream regulatory elements are necessary and sufficient for transcription of U6 RNA gene by RNA polymerase III".
Dipaolo et al., 1993, Critical Reviews in Oncogenesis 00:1-23, "Cellular and Molecular Alteratins in Human Epithelial Cells Transformed by Recombinant Human Papillomavirus DNA".
Doeberitz et al., 1992, Int. J. Cancer, 51:831-834, "Inhibition of tumorigenicity of cervical cancer cells in nude mice by HPV E6-E7 anti-sense RNA".
Felgner et al., 1993, Methods: Companion to Methods in Enzymology 5(1):67-75, "Cationic Lipid-Mediated Delivery of Polynucleotides".
Forster and Symons, 1987, Cell 49:211-220, "Self-Cleavage of Plus and Minus RNAs of a Virusoid and Structural Model for the Active Sites".
Hampel and Tritz, 1989, Biochem. 28:4929-4933, "RNA Catalytic Properties of the Minimum (-)sTRSV Sequence".
Hampel et al., 1990, Nucleic Acids Res. 18:299-304, "Hairpin catalytic RNA model: evidence for helices and sequence requirement for substrate RNA".
Haseloff and Gerlach, 1988, Nature 334:585-591, "Simple RNA enzymes with new and highly specific endoribonuclease activies" (Aug.).
Mulligan, 1993, Science, 260:926-932, "The Basic Science of Gene Therapy" (May).
Nasseri et al., 1991, Virology 184:131-140, "Human Papillomavirus Type 16 Immortalized Cervical Keratinocytes Contain Transcripts Encoding E6, E7, and E2 Initiated at the P97 Promoter . . .".
Ojwang et al., 1992, Proc. Natl. Acad. Sci 89:10802-10806, "Introductory Remarks on the General Application of Antisense".
Rossi, 1993, Methods: Companion to Methods in Enzymology 5:1-5, "Introductory Remarks on the General Application of Antisense RNAs and Ribozymes".
Sambrook, 1989, Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab Press) 1.25-1.28; 1.60-1.61; 1.68-1.69; 1.82-1.84; 6.9-6.13, 6:46-6.48.
Sarver et al., 1990, Gene Regulation and Aids, pp. 305-325 "Exploring Catalytic RNAs (Ribozymes) as Anti-HIV Agents".
Sedman et al., 1991,J. Virology, 65:4860-4866, "The Full-Length E6 Protein of Human Papillomavirus Type 16 Has Transforming and trans-Activating Activies and Cooperates with E7 . . .".
Smotkin et al., 1989, J. Virology, 63:1441-1447, "Oncogenic and Nononcogenic Human Genital Papillomaviruses Generate the E7 mRNA by Different Mechanisms".
Smotkin and Wettstein, 1986, Proc. Nat. Acad. Sci. 83:4680-4684 "Transcription of human papillomavirus type 16 early genes in cervical cancer-derived cell line and identification of the E7 protein".
Steele et al., 1993, Cancer Research 53:2330-2337, "Effects of Human Papillomavirus Type 18-specific Antisense Oligonucleotides on the Transformed Phenotype of Human Carcinoma Cell Lines".
Storey et al., 1991, Nucleic Acids Research 19(15):4109-4114, "Anti-sense phosphorothioate oligonucleotides have both specific and non-specific effects on cells containing human papillomavirus type 16".
Sullivan, 1993, Methods: Companion to Methods in Enzymology 5(1):61-66"Liposome-Mediated Uptake of Ribozymes".
Uhlenbeck, 1987, Nature, 328:596-600, "A small catalytic oligoribonucleotide".
Varani et al., 1991, Biochem, 30:3280-3289, "Structure of an Unusually Stable RNA Hairpin".
Yu et al., 1993, Proc. Natl. Acad. Scie. 90:6340-6344, "A hairpin inhibits expression of diverse strains of human immunodeficiency virus type 1.".
He et al (1993) FEBS Letts. 322, 21-24.
DiPaolo Joseph
Galasinski Scott C.
Hampel Arnold
Siwkowski Andrew M.
Elliott George G.
McGarry Sean
Northern Illinois University
United States of America as represented by the Department of Hea
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