Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-05-20
1996-11-19
Ketter, James S.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4353201, C12N 522, C12N 1585
Patent
active
055762069
ABSTRACT:
A process of immortalizing cells with isolated HPV-16, 18, 31, 33 or 35 E6 and E7 genes or the E7 gene alone to produce non-tumorigenic immortalized cell lines which retain the differentiated phenotypic characteristics of the parent cells.
REFERENCES:
patent: 4885238 (1989-12-01), Reddel et al.
patent: 5376542 (1994-12-01), Schlegel
Willey et al., Cancer Research, vol. 51, 1991, pp. 5370-5377.
Banks et al., J. Immunology, vol. 146, 1991, pp. 2037-2042.
Widdicombe, American J. Physiology, vol. 251, 1986, pp. R818-R822.
"Neoplastic Transformation in Human Cell Culture", copyright 1991 by The Humana Press Inc., Papers from a workshop held at Georgetown University Medical Center, Washington, D.C. on Apr. 25-26, 1991.
Abstracts of papers presented at the 1991 Papillomavirus Workshop, Jul. 20-26, 1991 in Seattle, Washington on the campus of the University of Washington.
"Inverse Relationship Between Human Papillomavirus (HPV) Type 16 Early Gene Expression and Cell Differentiation in Nude Mouse Epithelial Cysts and Tumors Induced by HPV-Positive Human Cell Lines", Journal of Virology, vol. 65, No. 2, pp. 796-804, Feb. 1991.
Notes on "The E6 and E7 Genes of the Human Papillomavirus Type 16 Together are Necessary and Sufficient for Transformation of Primary Human Keratinocytes", Journal of Virology, vol. 63, No. 10, pp. 4417-4421, Oct. 1989.
Short Report on "The E6 and E7 Genes of HPV-18 are Sufficient for Inducing Two-Stage In Vitro Transformation of Human Keratinocytes", The Macmillan Press Ltd., 1989, Oncongene (1989), 4, 1529-1532.
"Differences in Transformation Activity Between HPV-18 and HPV-16 Map to the Viral LCR-E6-E7 Region", Virology 181, 374-377 (1991) by Luisa Lina Villa and Richard Schlegel.
"Immortalization and Altered Differentiation of Human Keratinocytes in Vitro by the E6 and E7 Open Reading Frames of Human Papillomavirus Type 18", Journal of Virology, vol. 64, No. 2, pp. 519-526, Feb. 1990.
"Altered Expression of Proliferation and Differentiation Markers in Human Papillomavirus 16 and 18 Immortalized Epithelial Cells Grown in Organotypic Culture", American Journal of Pathology, vol. 140, No. 1, Jan. 1992.
"The E7 Gene of Human Papillomavirus Type 16 is Sufficient for Immortalization of Human Epithelial Cells", Journal of Virology, vol. 65. No. 1, pp. 473-478, Jan. 1991.
"Immortalization of Normal Human Bronchial Eipthelial cells by Human Papillomaviruses 16 or 18", Cancer Research, 51, 5370-5377, Oct. 1, 1991.
"Loss of p53 Protein in Human Papillomavirus Type 16 E6-Immortalized Human Mammary Epithelial Cells", Journal of Virology, vol. 65, No. 12, pp. 6671-6676, Dec. 1991.
"Human Cervical and Foreskin Eipthelial Cells Immortalized by Human Papillomavirus DNAs Exhibit Dysplastic Differentiation In Vivo", Cancer Research, 50, 3709-3715, Jun. 15, 1990.
"Epithelial Cells Immortalized by Human Papillomaviruses Have Premalignant Characteristics in Organotypic Culture", American Journal of Pathology, vol. 138, No. 3, Mar. 1991.
"In Vitro Biological Activities of the E6 and E7 Genes Vary Among Human Papillomaviruses of Different Oncogenic Potential", Journal of Virology, vol. 65, No. 1, pp. 292-298, Jan. 1991.
"Epithelial Cells Immortalized by Human Papillomaviruses Have Premalignant Characteristics in Organotypic Culture", American Journal of Pathology, vol. 138, No. 3, pp. 673-685, Mar. 1991.
Georgetown University
Ketter James S.
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