Human pancreatic GRF

Details Human pancreatic GRF Human pancreatic GRF

1982-10-04

1986-01-07

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

2601125R, C07C10352, A61K 3702

Patent

active

045633525

ABSTRACT:
Human pancreatic GRF has been synthesized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in mammals and which have the formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-R.sub.15 -Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-S er-Asn-Gln-Glu-Arg-Gly-R.sub.40 -R.sub.41 -R.sub.42 -Y wherein R.sub.15 is Gly or D-Ala, R.sub.40 is Ala or des-R.sub.40, R.sub.41 is Phe or des-R.sub.41, R.sub.42 is des-R.sub.42 or 1 to 8 different amino acid residues selected from the group consisting of Gln, Gly, Ile, Leu, Lys, Pro, Thr and Val, and Y signifies the carboxyl moiety of the amino acid residue at the C-terminal and is the radical -COOR.sub.1,-CR.sub.1 O,-CONHNHR.sub.1,-CON(R.sub.1)(R.sub.2) or -CH.sub.2 OR.sub.1, with R.sub.1 and R.sub.2 being lower alkyl or hydrogen. These peptides or biologically active fragments thereof, or analogs thereof having well-known substitutions and/or additions, as well as nontoxic salts of any of the foregoing, may be administered therapeutically to animals, including humans, and may be used diagnostically.

REFERENCES:
patent: 4218474 (1980-08-01), Barnish et al.
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Esch et al., The Journal of Biological Chemistry, 258, No. 3, 1806-1812 (1983).
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Veber et al., Biochem. & Biophys. Res. Commun., 45, No. 1, 235-9 (1971).
Frohman et al., Clin. Invest., 65, 43-54 (1980).
Spiess et al., Biochemistry, vol. 21, 1982, pp. 6037-6040.
Spiess et al., Nature, vol. 303, 1983, pp. 532-535.
Tharner et al., The Lancet, Jan. 1/8, 1983, pp. 24-28.
Rivier et al., 8th American Peptide Symposium, May 22-27, 1983, Tucson, Arizona, p. 237.
Spiess et al., Biochemistry, 21, 6037-6040 (1982).
Spiess et al., Nature, 303 (9), 532-535 (1983).
Tharner et al., The Lancet, No. 831415, 24-28 (1983).

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