Human pancreatic cell lines: developments and uses

Details Human pancreatic cell lines: developments and uses Human pancreatic cell lines: developments and uses

1995-07-31

1998-03-03

Elliott, George G.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4353201, 435377, 435378, C12N 500, C12N 508, C12N 522, C12N 1563

Patent

active

057233330

ABSTRACT:
This invention relates to cell lines, particularly mammalian cell lines, established by transforming the cells with vectors, preferably retroviral vectors, containing two or more oncogenes under the control of one or more inducible promoters and/or genetic elements. Also within the scope of the invention are human cell lines with extended in vitro lifespan, transformed by vectors containing one or more oncogenes under the control of one or more, preferably exogenous, inducible promoters and/or genetic elements. The vectors may additionally contain gene(s) encoding for desired gene product(s). Also disclosed are insulin producing human pancreatic cell lines useful for transplantation into human diabetic patients.

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