Human p21-activated kinase 5 polypeptide

Details Human p21-activated kinase 5 polypeptide Human p21-activated kinase 5 polypeptide

2006-02-28

2006-02-28

Steadman, David J. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

Reexamination Certificate

active

07005285

ABSTRACT:
The present invention provides a human polypeptide homolog of P21-activated kinase (PAK) polynucleotides which identify and encode PAK5serine/threonine kinase. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of PAK5agonists/antagonists, useful for the treatment of human diseases and conditions.

REFERENCES:
patent: 6013500 (2000-01-01), Minden
patent: WO 99/53036 (1999-10-01), None
patent: WO 00/58473 (2000-10-01), None
Branden et al. “Introduction to Protein Structure”, Garland Publishing Inc., New York, 1991.
Witkowski et al. (1999)Biochemistry 38:11643-11650.
GenBank Accession No. AB033090, Nov. 11, 1999.
New England Biolabs 1996/97 Catalog, p. 147.
Abo, A. et al., “PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia”,EMBO Journal,1998, 17(22), 6527-6540.
Bagrodia, S. et al., “PAK to the Future”,Trends in Cell Biology,1999, 9, 350-355.
Bagrodia, S. et al., “A Tyrosine-phosphorylated Protein That Binds to an Important Regulatory Region on the Cool Family of p21-activated Kinase-binding Proteins”,J. Biol. Chem.,1999, 274(32), 22393-400.
Bagrodia, S. et al., “A Novel Regulator of p21-activated Kinases”,J. Biol. Chem.,1998, 273(37), 23633-23636.
Bokoch, G.M. et al., “Interaction of the Nck Adapter Protein with p21-activated Kinase (PAK1)”,J. Biol. Chem.,1996, 271(42), 25746-25749.
Bokoch, G.M. et al., “A GTPase-independent Mechanism of p21-activated Kinase Activation”,J. Biol. Chem.,1998, 273(14), 8137-8144.
Burbelo, P.D. et al., “A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases”,J. Biol. Chem.,1995, 270(49), 29071-29074.
Hanks, S.K. et al., “Protein Kinase Catalytic Domain Sequence Database: Identification of Conserved Features of Primary Structure and Classification of Family Members”,Methods in Enzymology,1991, 200, 38-62.
Lian, J.P. et al., “Products of Sphingolipid Catabolism Block Activation of the p21-Activated Protein Kinases in Neutrophils”,J. Immunol.,1998, 161, 4375-4381.
Manser, E. et al., “PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors”Molecular Cell.,1998, 1, 183-192.
Nagase, T. et al., “Prediction of the Coding Sequences of Unidentified Human Genes. XV. The Complete Sequences of 100 New cDNA Clones From Brain which Code for Large Proteins in Vitro”,DNA Research,1999, 6(5), 337-345.
Tang, Y. et al., “A role for Pak protein kinases in Schwann cell transformation”,Proc. Natl. Acad. Sci USA,1998, 95, 5139-5144.
Watanabe, N.M. et al., “PAK5, A Novel Group II Pak Family Kinase that id Predominately Expressed in Brain”, 2000, XP002164869, pp. 1-2.
Yablonski, D. et al., “A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK”,EMBO J.,1998, 17(19), 5647-5657.
Bridgeman, A. “Human DNA Sequence from Clone RP5-1119D9 on Chromosome 20p12”,Direct Submission,Dec. 1, 2000, GenBank ACCESSION # AL 031652.
Melzig, J. et al., “A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in theDrosophilaadult central nervous system”,Current Biology,1998, 8, 1223-1226.
Ohara, O. et al., “Construction and Characterization of Human Brain cDNA Libraries Suitable for Analysis of cDNA Clones Encoding Relatively Large Proteins”,DNA Research,1997, 4, 53-59.

Affiliated with

Also associated with

Rating

Human p21-activated kinase 5 polypeptide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human p21-activated kinase 5 polypeptide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human p21-activated kinase 5 polypeptide will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3653089