Human oxalyl-CoA decarboxylase

Details Human oxalyl-CoA decarboxylase Human oxalyl-CoA decarboxylase

1995-06-02

1997-06-03

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 703, 435 9141, 435348, 435325, 435358, 435365, 435419, 435357, 435367, C07H 2102, C07H 2104, C12Q 168, C12P 2104

Patent

active

056356161

ABSTRACT:
A human oxalyl-CoA decarboxylase polypeptide and DNA(RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.

REFERENCES:
patent: 5547870 (1996-08-01), Datta et al.
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Lung, et al., Journal of Bacteriology, Apr. 1994, pp. 2468-2472, vol. 176, No. 8.
Lung, et al., American Journal of Kidney Diseases, vol. XVII, No. 4 (Apr.), 1991; pp. 381-385.
Mehta, et al., The Journal of Biological Chemistry, vol. 266, No. 35, Issue of Dec. 15, pp. 23548-23553, 1991.
Allison, M., et al., Arch Microbiol, 141:1-7 (1985).
Triebig, et al., Clinica Chimica Acta., 108 (1980) 355-360.
Chemical Abstracts, vol. 118, No. 15, p. 406 (Apr. 12, 1993).
Quayle, J. R. (1969) Methods in Enzymology 13:369-372.

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