Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1990-10-30
1999-02-09
Duffy, Patricia
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435325, 435368, 436503, 436 63, 436811, G01N 3353
Patent
active
058692665
ABSTRACT:
The present invention relates to a culture of human olfactory neurons. The neurons may display a normal neuronal pathology or a pathology characteristic of a generalized central nervous system disease. The cultured neurons can be used for neurotoxicity tests, screening for therapeutic drugs and anti-viral agents, and diagnosing Alzheimer's disease.
REFERENCES:
patent: 4829000 (1989-05-01), Kleinman et al.
Montgomery et al., Developmental Biology 117, 64-70 (1986) Morphogenesis in Vitro of Dissociated Fetal Rat Small Intestinal Cells upon an Open Surface and Subsequent to Collagen Gel Overlay.
Calof et al. Neuron 3: 115-127, 1989.
Wolozin et al. Science 232: 648-650, 1986.
Cole et al. Biochem. Biophys. Res. Comm. 170(1): 288-295, 1990.
Kleinman et al in The Role of Extracellular Matrix in Development, Alan R. Liss, Inc.: New York, pp. 123-143 (1984).
Lovell et al. Arch. Otolaryngol. 108: 247-249, 1982.
Yankner et al. Science 245: 417-420, 1989.
The Washington Post, "Tracking Alzheimer's: Tangles in Brain Cells Believed to Hold Key", 25 Feb. 1991.
Mari, J., Science, vol. 249, pp. 984-985 (31 Aug. 1990).
Talamo et al., Nature, vol. 337(23), pp. 736-739 (Feb. 1989).
Mita et al., Biological Abstracts, Abstract #85113, vol. 88 (1989).
Serby et al. "Olfactory Dysfunction in Alzheimer's Disease and Parkinsons' Disease" Am. J. Psychiatry vol. 142:6. Jun. 1985 pp. 781-782.
Coon et al. "Cell Cultures of Neuroblasts from Rat Olfactory Epithelium that Show Odorant Responses" Proc. Natl. Academy Sci. USA vol. 86 Mar. 1989 pp. 1703-1707.
Tomonaga et al. "Approach to Dementia Research". Rinsho Shinkeigaku, vol. 29 (12) Dec. 1989 pp. 1532-1535 (Abstract).
Card et al. "Immunocytochemical Localization of the Precursor Protein for Beta-Amyloid in the Rat Central Nervous System" Neuron vol. 1(9) Nov. 1988 pp. 835-846 (Abstract).
Mann et al "Alzheimer's Disease and Olfactory Connection?" Mech Ageing Dev. vol. 42 (1) 1988 pp. 1-16 (Abstract).
Takahashi et al "Progressive Supranuclear Palsy with Limbic System Involvement Report of a Case With Ultrastructural Investigation of Neurofibrillary Tangles in Various Locations" Clinical Neuropathology vol. 6(6) 1987 pp. 271-276 (Abstract).
Ohm et al. "Olfactory Bulb Changes in Alzheimer's Disease" Acta Neuropathologica. vol. 73 (4) 1987 pp. 365-369 (Abstract).
Coon Hayden G.
Wolozin Benjamin L.
Duffy Patricia
The United States of America as represented by the Department of
LandOfFree
Human olfactory neuron cultures to diagnose Alzheimer's disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human olfactory neuron cultures to diagnose Alzheimer's disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human olfactory neuron cultures to diagnose Alzheimer's disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1947687