Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-12-22
2000-09-26
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435195, 4352522, 4353201, 536 232, 536 235, 530300, 530350, C12Q 168, C12N 914, C12N 120, C07H 2104
Patent
active
061240958
ABSTRACT:
The invention provides a human nucleotide pyrophosphohydrolase-2 (NTPPH-2) and polynucleotides which identify and encode NTPPH-2. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NTPPH-2.
REFERENCES:
Swan, A. et al., "Submicroscopic crystals in osteoarthritic synovial fluids" Ann.Rheum.Dis. (1994) 53:467-470.
Lohmander, L.S. et al., "Metalloproteinases, Tissue Inhibitor, and Proteoglycan Fragments in Knee Synovial Fluid in Human Osteoarthritis" Arthritis Rheum. (1993) 36:181-189.
Ryan, L.M. et al., "Adenosine Triphosphate Levels in Human Plasma" J.Rheumatol. (1996) 23:214-219.
Park, W. et al., "Inorganic Pyrophosphate Generation from Adenosine Triphosphate by Cell-Free Human Synovial Fluid" J.Rheumatol. (1996) 23:665-671.
Derfus, B.A. et al., "Articular Cartilage Vesicles Generate Calcium Pyrophosphate Dihydrate-Like Crystals in Vitro" Arthritis Rheum. (1992) 35:231-240.
Cardenal, A. et al., "Identification of a Nucleotide Pyrophosphohydrolase from Articular Tissues in Human Serum" Arthritis Rheum. (1996) 39:252-256.
Cardenal, A. et al., "Specificity of a Porcine 127-KD Nucleotide Pyrophosphohydrolase for Articular Tissues" Arthritis Rheum. (1996) 39:245-251.
Masuda, I. et al., "A Unique ectonucleotide pyrophosphohydrolase associated with porcine chondrocyte-derived vesicles" J.Clin.Invest. (1995) 95:699-704 (abstract attached).
Masuda, I. et al., "Molecular cloning and expression of a porcine chondrocyte nucleotide pyrophohydrolase" Gene (1997) 197:277-287 (abstract attached).
Suggs et al. PNAS. 78(11):6613-17 (1981).
Lorenzo, P. et al., "Cloning and Deduced Amino Acid Sequence of a Novel Cartilage Protein (CILP) Identifies a Proform Including a Nucleotide Pyrophosphohydrolase", J. Biol. Chem. 273:23469-23475 (1998).
Hutchinson Nancy
Lawton Michael
Magna Holly
Mitchell Peter
Murry Lynn E.
Achutamurthy Ponnathapu
Incyte Pharmaceuticals Inc.
Saidha Tekchand
Streeter David G.
LandOfFree
Human nucleotide pyrophosphohydrolase-2 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human nucleotide pyrophosphohydrolase-2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human nucleotide pyrophosphohydrolase-2 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2098814