Human nucleotide pyrophosphohydrolase-2

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435195, 4352522, 4353201, 536 232, 536 235, 530300, 530350, C12Q 168, C12N 914, C12N 120, C07H 2104

Patent

active

061240958

ABSTRACT:
The invention provides a human nucleotide pyrophosphohydrolase-2 (NTPPH-2) and polynucleotides which identify and encode NTPPH-2. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NTPPH-2.

REFERENCES:
Swan, A. et al., "Submicroscopic crystals in osteoarthritic synovial fluids" Ann.Rheum.Dis. (1994) 53:467-470.
Lohmander, L.S. et al., "Metalloproteinases, Tissue Inhibitor, and Proteoglycan Fragments in Knee Synovial Fluid in Human Osteoarthritis" Arthritis Rheum. (1993) 36:181-189.
Ryan, L.M. et al., "Adenosine Triphosphate Levels in Human Plasma" J.Rheumatol. (1996) 23:214-219.
Park, W. et al., "Inorganic Pyrophosphate Generation from Adenosine Triphosphate by Cell-Free Human Synovial Fluid" J.Rheumatol. (1996) 23:665-671.
Derfus, B.A. et al., "Articular Cartilage Vesicles Generate Calcium Pyrophosphate Dihydrate-Like Crystals in Vitro" Arthritis Rheum. (1992) 35:231-240.
Cardenal, A. et al., "Identification of a Nucleotide Pyrophosphohydrolase from Articular Tissues in Human Serum" Arthritis Rheum. (1996) 39:252-256.
Cardenal, A. et al., "Specificity of a Porcine 127-KD Nucleotide Pyrophosphohydrolase for Articular Tissues" Arthritis Rheum. (1996) 39:245-251.
Masuda, I. et al., "A Unique ectonucleotide pyrophosphohydrolase associated with porcine chondrocyte-derived vesicles" J.Clin.Invest. (1995) 95:699-704 (abstract attached).
Masuda, I. et al., "Molecular cloning and expression of a porcine chondrocyte nucleotide pyrophohydrolase" Gene (1997) 197:277-287 (abstract attached).
Suggs et al. PNAS. 78(11):6613-17 (1981).
Lorenzo, P. et al., "Cloning and Deduced Amino Acid Sequence of a Novel Cartilage Protein (CILP) Identifies a Proform Including a Nucleotide Pyrophosphohydrolase", J. Biol. Chem. 273:23469-23475 (1998).

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