Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1981-08-12
1984-02-28
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435172, 435948, 435241, C12N 500, C12N 502, C12N 1500, C12R 191
Patent
active
044342306
ABSTRACT:
A human non-secretory plasmacytoid continuous cell line, established for five years in more than 150 passages, is karyotypically normal, easily grown and has the characteristic features of a plasmablast excepting for its secretory defect, and can be used for the preparation of human-human hybridomas with human B-lymphocytes and separation of the resulting hybridomas from the plasmacytoma cell line by growth in CO.sub.2 -containing media, or by fluorescence activated cell sorting, or both.
REFERENCES:
Olsson et al., "Human-Human Hybridomas Producing Monoclonal Antibodies of Pre-defined Antigenic Specificity", Proceedings of the National Academy of Sciences 77(9), (1980), pp. 5429-5431.
Croce et al., "Production of Human Hybridomas Secreting Antibodies to Measles Virus" Nature 288, (12-1980), pp. 488-489.
Steel et al., "Possibility of EB Virus Preferentially Transforming a Subpopulation of Human B Lymphocytes", Nature 270, (12-1977), pp. 729-731.
Levy et al., "Rescue of Immunoglobin Secretion from Human Neoplastic Lymphoid Cells By Somatic Cell Hybridization" Proceedings of the National Academy of Sciences 75(5), (1978), pp. 2411-2415.
Newswatch, "Scots Develop New Way to Make Human Hybridomas", Monday, Jul. 6, 1981, p. 6.
Lundak et al., "Production of Human Human Secreting Specific Antibody", Abstracts of the Annual Meeting of the American Society for Microbiology, 1981, vol. 81 (9), p. 62.
Research Corporation
Tarcza John Edward
Wiseman Thomas G.
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