Human NK-3 related prostate specific gene-1

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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53, C530S402000

Reexamination Certificate

active

07351694

ABSTRACT:
The present invention relates to a novel member of the NK family of homeobox genes. In particular, isolated nucleic acid molecules are provided encoding the human NK-3 prostate specific gene 1 (NKX3.1) protein. NKX3.1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of NKX3.1 activity. Also provided are diagnostic methods for detecting prostate cancer and other cancers and therapeutic methods for prostate cancer and other cancers.

REFERENCES:
patent: 5194596 (1993-03-01), Tischer et al.
patent: 5350836 (1994-09-01), Kopchick et al.
patent: WO-95/32214 (1995-11-01), None
patent: WO-97/20942 (1997-06-01), None
ATCC search output (pp. 1-8).
Benjamin et al., Development 125:1591-1598 (1998).
Vukicevic et al., PNAS USA 93:9021-9026 (1996).
Massague, Cell 49:437-438 (1987).
Pilbeam et al., Bone 14:717-720 (1993).
Skolnick et al., Trends in Biotech. 18:34-39 (2000).
Bork, Genome Research 10:398-400 (2000).
Doerks et al., Trends in Genetics 14:248-250 (1998).
Smith et al., Nature Biotechnology 15:1222-1223 (1997).
Brenner, Trends in Genetics 15:132-133 (1999).
Bork, Trends in Genetics 12:425-427 (1996).
Bowie et al., Science 247:1306-1310 (1990).
Alberts et al., (Molecular Biology of the Cell, 3rd edition, 1994, p. 465.
Genes VI (1997) by Benjamin Lewin.
Greenbaum et al., Genome Biology vol. 4, Issue 9, pp. 117.1-117.8 (2003).
Burgess et al., Journal of Cell Biology vol. 111: 2129-2138 (Nov. 1990).
Lazar et al., Molecular and Cellular Biology vol. 8 No. 3 1247-1252 (Mar. 1988).
Schwartz et al., Proc Natl Acad Sci USA vol. 84:6408-6411 (1987).
Lin et al., Biochemistry USA vol. 14:1559-1563 (1975).
Sciavolino et al. (Developmental Dynamics 209:127-138 (May 1997).
Sequence alignment output for aa 124-183 of SEQ ID No. 2 and Sciavolino (1 page).
Bieberich et al. (J. Biol. Chem. 271:31779-31782 (Dec. 13, 1996).
Sequence alignment output for aa 124-183 of SEQ ID No. 2 and Bieberich (1 page).
Bova, G.S. et al., “Homozygous Deletion and Frequent Allelic Loss of Chromosome 8p22 Loci in Human Prostrate Cancer,”Cancer Res., 53:3869-3873 (1993).
Gehring, W.J. et al., Homeodoma in Proteins,Annu. Rev. Biochem., 63:487-526 (1994).
Ichikawa, T. et al., “Suppression of Metastasis of Rat Prostatic Cancer by Introducing Human Chromosome 8,”Cancer Res., 54:2299-2302 (1994).
Kim, Y. and M. Nirenberg, “Drosophila NK-homeobox genes,”Proc. Natl. Acad. Sci. USA, 86:7716-7720 (1989).
Kissinger, C.R. et al., “Crystal Structure of an engrailed Homeodomain-DNA Complex at 2.8 Resolution: A Framework for Understanding Homeodomain-DNA Interactions,”Cell, 63:579-590 (1990).
Konig, J.J. et al., “Cytogenetic characterization of several androgen responsive and unresponsive sublines of the human prostatic carcinoma cell line LNCaP,”Urol. Res., 17:79-86 (1989).
Krumlauf, R., “HoxGenes in Vertebrate Development,”Cell78:191-201 (1994).
Laughon, A. and M.P. Scott, “Sequence of aDrosophilasegmentation gene: protein structure homology with DNA-binding proteins,”Nature310:25-31 (1984).
Lints, T.J. et al., “Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants,”Development119:419-431 (1993).
Macoska, J.A. et al., “Evidence for Three Tumor Suppressor Gene Loci on Chromosome 8p in Human Prostate Cancer,”Cancer Res. 55:5390-5395 (1995).
MacGrogan, D. et al., “Loss of Chromosome Arm 8p Loci in Prostate Cancer: Mapping by Quantitative Allelic Imbalance,”Genes, Chromosomes&Cancer10:151-159 (1994).
McGinnis, W. and R. Krumlauf, “Homeobox Genes and Axial Patterning,”Cell68:283-302 (1992).
Otting, G. et al., “Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution,”EMBO J. 9:3085-3092 (1990).
Price, M. et al., “Regional Expression of the Homeobox GeneNkx-2.2 in the Developing Mammalian Forebrain,”Neuron8:241-255 (1992).
Shepherd, J.C.W. et al., “Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins,”Nature310:70-71 (1984).
Stein, S. et al., “Checklist: Vertebrate homeobox genes,”Mech. Develop. 55:91-108 (1996).
Suzuki, H. et al., “Localization of a Tumor Suppressor Gene Associated With Progression of Human Prostate Cancer Within a 1.2 Mb Region of 8p22-p21.3,”Genes, Chromosomes&Cancer13:168-174 (1995).
Trapman, J. et al., “Loss of Heterozygosity of Chromosome 8 Microsatellite Loci Implicates a Candidate Tumor Suppressor Gene between the LociD8S87andD8S133in Human Prostate Cancer,”Cancer Res. 54:6061-6064 (1994).
Vocke, C.D. et al., “Analysis of 99 Microdissected Prostate Carcinomas Reveals a High Frequency of Allelic Loss on Chromosone 8p12-21,”Cancer Res. 56:2411-2416 (May 1996).
NCBI Entrez, Genbank Report, Accession No. T72229, Hillier, L. et al. (1995).
NCBI Entrez, Genbank Report, Accession No. T65197, Hillier, L. et al. (1995).
NCBI Entrez, Genbank Report, Accession No. F11981, Auffray, C. et al. (1995).
NCBI Entrez, Genbank Report, Accession No. F13543, Auffray, C. et al. (1995).
NCBI Entrez, Genbank Report, Accession No. R08437, Hillier, L. et al. (1995).
NCBI Entrez, Genbank Report, Accession No. R30778, Hillier, L. et al. (1995).
NCBI Entrez, Genbank Report, Accession No. AA077087, Touchman, J.W. et al. (Oct. 1996).
NCBI Entrez, Genbank Report, Accession No. W50633, Marra, M. et al. (May 1996).
NCBI Entrez, Genbank Report, Accession No. W59023, Marra, M. et al. (Jun. 1996).
NCBI Entrez, Genbank Report, Accession No. W77296, Marra, M. et al. (Jun. 1996).
NCBI Entrez, Genbank Report, Accession No. W99235, Marra, M. et al. (Jul. 1996).
NCBI Entrez, Genbank Report, Accession No. AA019401, Hillier, L. et al. (Aug. 1996).
NCBI Entrez, Genbank Report, Accession No. F14521, Wintero, A.K. et al. (Sep. 1996).
NCBI Entrez, Genbank Report, Accession No. AA082163, Hillier, L. et al. (Oct. 1996).
NCBI Entrez, Genbank Report, Accession No. AA126727, Hillier, L. et al. (Nov. 1996).
NCBI Entrez, Genbank Report, Accession No. AA181926, Hillier, L. et al. (Jan. 1997).
NCBI Entrez, Genbank Report, Accession No. AA187553, Hillier, L. et al. (Jan. 1997).
NCBI Entrez, Genbank Report, Accession No. AA017789, Marra, M. et al. (Jan. 1997).
NCBI Entrez, Genbank Report, Accession No. AA063092, Hillier, L. et al. (Feb. 1997).
NCBI Entrez, Genbank Report, Accession No. AA063646, Hillier, L. et al. (Feb. 1997).
NCBI Entrez, Genbank Report, Accession No. AA062412, Marra, M. et al. (Feb. 1997).
NCBI Entrez, Genbank Report, Accession No. AA154256, Marra, M. et al. (Feb. 1997).
NCBI Entrez, Genbank Report, Accession No. AA145840, Marra, M. et al. (Feb. 1997).
NCBI Entrez, Genbank Report, Accession No. AA238720, Marra, M. et al. (Mar. 1997).
NCBI Entrez, Genbank Report, Accession No. AA268724, Marra, M. et al. (Mar. 1997).
NCBI Entrez, Genbank Report, Accession No. AA305563, Adams, M.D. et al. (Apr. 1997).
NCBI Entrez, Genbank Report, Accession No. AA386139, Adams, M.D. et al. (Apr. 1997).
NCBI Entrez, Genbank Report, Accession No. AA053456, Hillier, L. et al. (May 1997).
NCBI Entrez, Genbank Report, Accession No. AA453083, Hillier, L. et al. (Jun. 1997).
NCBI Entrez, Genbank Report, Accession No. AA472699, Marra, M. et al. (Jun. 1997).
NCBI Entrez, Genbank Report, Accession No. AA522394, Marra, M. et al. (Jul. 1997).
NCBI Entrez, Genbank Report, Accession No. AA494677, Clark, M. et al. (Jun. 1997).
NCBI Entrez, Genbank Report, Accession No. AA542622, Clark, M. et al. (Jul. 1997).
NCBI Entrez, Genbank Report, Accession No. C26874, Yamamoto, K. and Sasaki, T. (Aug. 1997).
NCBI Entrez, Genbank Report, Accession No. AA492170, NCI-CGAP (Aug. 1997).
NCBI Entrez, Genbank Report, Accession No. AA560411, Marra, M. et al. (Aug. 1997).
NCBI Entrez, Genbank Report, Accession No. AA576890, NCI-CGAP (Sep. 19

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