Human NIK proteins

Details Human NIK proteins Human NIK proteins

1998-02-13

1998-12-01

McKelvey, Terry A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530324, 530325, 530326, 530327, 530328, 530350, C07K 412, C07K 706, C07K 708, C07K 1447

Patent

active

058440739

ABSTRACT:
The invention provides methods and compositions relating to a novel kinase, NIK, involved in NF.kappa.B activation. The polypeptides may be produced recombinantly from transformed host cells from the disclosed NIK encoding nucleic acids or purified from human cells. The invention provides isolated NIK hybridization probes and primers capable of specifically hybridizing with the disclosed NIK genes, NIK-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

REFERENCES:
Malinin et al, Nature, vol. 385, pp. 540-544, Feb. 6, 1997.

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