Human neurotensin receptor type 2 and splice variants thereof

Details Human neurotensin receptor type 2 and splice variants thereof Human neurotensin receptor type 2 and splice variants thereof

1999-08-11

2000-12-26

Elliott, George C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530300, C07K 1400, C07K 500

Patent

active

061661821

ABSTRACT:
Human neurotensin type 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing human neurotensin type 2 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

REFERENCES:
GenBank Accession #1640787, Apr. 19, 1997.
P. Chalon, et al., "Molecular cloning of a levocabastine-sensitive neurotensin binding site", FEBS Letters vol. 386, pp. 91-94 (1996).
J. Mazella, et al., "Structure, Functional Expression, and Cerebral Localization of the Levocabastine-Sensitive Neurotensin/Neuromedin N Receptor from Mouse Brain", The Journal of Neuroscience, vol. 16 5613-5620, Sep. 15, 1996.

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